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Relationship between sperm tail morphology and sperm motility parameters |
WANG Gaigai WANG Jiaxiong SHEN Liyan HAN Mutian CHENG Hongbo LI Hong YANG Shenmin |
Reproductive and Genetic Center, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Jiangsu Province, Suzhou 215002, China |
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Abstract Objective To analyze the relationship between sperm tail morphology and sperm motility parameters. Methods A total of 15 398 specimens were collected from Reproductive and Genetic Center in Suzhou Municipal Hospital from November 2015 to December 2017. The samples were divided into asthenospermia group (4941 cases) and normal spermatozoa activity group (10 457 cases). The morphological malformation statistics of the two groups were collected. The relationship of sperm tail morphology and sperm motility parameters were analyzed. Results The abnormal morphology rates of asthenospermia group and normal group were significantly different (P < 0.05). There was statistically difference between asthenospermia group and the normal in mid piece angular bend [(9.41±3.62)% vs. (8.33±3.12)%], short [(1.34±2.87)% vs. (0.74±1.08)%], hairpin-like bend [(0.69±0.92)% vs. (0.64±0.81)%], curled [(8.83±4.09)% vs. (7.53±3.52)%], and main piece angular bend [(8.24±2.93)% vs. (7.65±2.58)%] (P < 0.05). The most common types of abnormal sperm tail morphology were mid piece angular bend, curling and main piece angular bend. Sperm motility gradually decreased as the proportion of the three kinds of malformations gradually increased. With the increase of the proportion of these three deformities sperm motility gradually malcreased, the differences were highly statistically significant (P < 0.01). Conclusion Sperm tail morphology malformation on sperm motility parameters has statistically influence. It is necessary to observe the sperm tail morphology of asthenospermia patients.
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[1] Ostermeier GC,Dix DJ,Miller D,et al. Spermatozoal RNA profiles of normal fertile men [J]. Lancet,2002,360(9335):772-777.
[2] Oates R. Evaluation of the azoospermic male [J]. Fertil Steril,2008,90(5):S74-S77.
[3] Loppin B,Lepetit D,Dorus S,et al. Origin and neofunctionalization of a Drosophila paternal effect gene essential for zygote viability [J]. Curr Biol,2005,15(2):87-93.
[4] Aitken RJ. Human spermatozoa:revelations on the road to conception [J]. F1000prime Rep,2013,5(5):39.
[5] 史轶超,沈丽燕,程洪波,等.精子形态与体外受精胚胎移植临床妊娠结局的关系[J].中华男科学杂志,2014,20(8):690-696.
[6] 马玉涵,刘睿智,许宗革,等.精子形态与精子运动参数关系研究[J].中华男科学杂志,2006,12(7):590-593.
[7] 世界卫生组织.世界卫生组织人类精液检查与处理实验室手册[M].谷翊群等译.北京:人民卫生出版社,2011.
[8] Lindemann CB,Lesich KA. Functional anatomy of the mammalian sperm flagellum [J]. Cytoskeleton (Hoboken),2016, 73(11):652-669.
[9] 王家雄,史轶超,杨慎敏.畸形精子超微结构观察的研究与应用进展[J].中华男科学杂志,2016,22(1):67-71.
[10] Westhoff D,Kamp G. Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa [J]. J Cell Sci,1997,110(15):1821-1829.
[11] Liu J,Sun CM,Zhang CL,et al. Location and characterization of GAPDS in male reproduction [J]. Urol Int,2013, 90(4):449-454.
[12] Auger J. Assessing human sperm morphology:top models, underdogs or biometrics? [J]. Asian J Androl,2010,12(1):36-46.
[13] Miki K,Qu W,Goulding EH,et al. Glyceraldehyde 3-phosphate dehydrogenase-S,a sperm-specific glycolytic enzyme,is required for sperm motility and male fertility [J]. Proc Natl Acad Sci USA,2004,101(47):16 501-16 506.
[14] Baba T,Kashiwagi Y,Arimitsu N,et al. Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics [J]. J Biol Chem,2014,289(16):11 497-11 511.
[15] Tang S,Wang X,Li W,et al. Biallelic mutations in CFAP43 and CFAP44 cause male infertility with multiple morphological abnormalities of the sperm flagella [J]. Am J Hum Genet,2017,100(6):854-864.
[16] Sha Y,Yang X,Mei L,et al. DNAH1 gene mutations and their potential association with dysplasia of the sperm fibrous sheath and infertility in the Han Chinese population [J]. Fertil Steril,2017,107(6):1312-1318.
[17] 韩瑞钰,王淑红,张香改,等.100%圆头精子症致不育1例并文献复习[J].疑难病杂志,2016,15(8):853-856, 881.
[18] 邓智标,黎子辉,麦贤昌.男性不育因素的临床研究[J].中国医学创新,2016,13(18):72-75.
[19] 李付彪,许宗革,齐威,等.精索静脉曲张对精子形态的影响[J].中国妇幼保健,2007,22(26):3689-3691.
[20] 郑慧杰,熊海云,余明主,等.青年精索静脉曲张程度与精液质量的相关性分析[J].中国男科学杂志,2016,30(7):54-56.
[21] 成艳君,李雪梅,周永红,等.精液白细胞与正常形态精子百分率的相关性分析[J].广州医药,2017,48(1):70-72.
[22] 李赟,杨帆,周俊彦,等.生殖道病原体感染对男性精液质量及精子形态学的影响[J].中华实验和临床感染病杂志:电子版:,2017,11(3):255-259.
[23] 邱峰龙,倪蓉,仲纪祥,等.不育男性不同影响因素与精子质量参数的关系研究[J].中国性科学,2017,26(5):112-115.
[24] Torabi F,Malekzadeh SM,Rezaei N. Combined protective effect of zinc oxide nanoparticles and melatonin on cyclophosphamide-induced toxicity in testicular histology and sperm parameters in adult Wistar rats [J]. Int J Reprod Biomed (Yazd),2017,15(7):403-412.
[25] 苏念军,朱伟杰,李菁,等.亚慢性口服氯化镉对成年大鼠睾丸生精功能的影响[J].生殖与避孕,2005,25(3):143-148.
[26] 索永善,叶玲玲,马川花,等.雷达微波辐射对精子形态的影响[J].中华男科学杂志,2007,13(12):1132-1133.
[27] 刘安娜,孙伟才.职业暴露对男性不育患者精液质量的影响分析[J].中国优生与遗传杂志,2015,23(10):119-120. |
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