涤痰化瘀汤对风痰入络证脑梗死急性期患者血清NO、ET水平的影响

Abstract
Figure/Table
References (25)
Related Citation (15)

Download: PDF (577 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of Ditan Huayu Decoction on serum nitric oxide (NO) and endothelin (ET) levels in patients with acute cerebral infarction of wind-phlegm invading collaterals syndrome. Methods From May 2017 to June 2020, 102 patients with acute cerebral infarction of wind-phlegm invading collaterals syndrome in Jiangyin Hospital of Traditional Chinese Medicine in Jiangsu Province were selected and divided into control group and study group according to random number table method, with 51 cases in each group. Control group was treated with conventional Western medicine, and study group was treated with Ditan Huayu Decoction on the basis of the treatment of control group. Two groups continued treatment for four weeks. Traditional Chinese medicine symptom score, serum NO and ET levels of wind-phlegm invading collaterals syndrome were compared between two groups before and after treatment. Clinical efficacy and safety of two groups were compared. Results Before treatment, there was no significant difference in traditional Chinese medicine symptom score, serum NO and ET levels between two groups (P > 0.05). After treatment, traditional Chinese medicine symptom score and serum NO level of wind-phlegm invading collaterals syndrome in two groups were lower than those before treatment, and study group was lower than that control group, the differences were statistically significant (P < 0.05). After treatment, the levels of serum ET in two groups were higher than those before treatment, and study group was higher than that control group the differences were statistically significant (P < 0.05). Total clinical effective rate of study group was higher than that of control group, the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P > 0.05). Conclusion Ditan Huayu Decoction is effective in treating patients with acute cerebral infarction of wind-phlegm invading collaterals syndrome. It can improve the vascular endothelial function of patients, and it is safe and reliable.

Key words： Acute cerebral infarction Wind-phlegm invading collaterals syndrome Nitric oxide Endothelin Ditan Huayu Decoction Safety Clinical efficacy

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Yuan XU Haogang▲

Cite this article:

WANG Yuan XU Haogang▲. Effect of Ditan Huayu Decoction on serum NO and ET levels in patients with acute cerebral infarction of wind-phlegm invading collaterals syndrome#br#[J]. 中国医药导报, 2022, 19(6): 127-130.

URL:

https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I6/127

[1] 张然，田浩林，王丽婷，等.静脉溶栓及血管内治疗急性脑梗死的国内研究进展[J].中华全科医学，2020，18（11）：1916-1920.
[2] 李强，周腾飞，贺迎坤，等.急诊血管内治疗急性前循环大面积脑梗死的疗效及影响因素分析[J].中华神经医学杂志，2020，19（7）：671-676.
[3] 李雪，贾子烨，李静，等.凝血纤溶标志物在急性脑卒中的临床研究进展[J].中国老年学杂志，2020，40（22）：4921-4924.
[4] 中国中西医结合学会神经科专业委员会.中国脑梗死中西医结合诊治指南（2017）[J].中国中西医结合杂志，2018， 38（2）：136-144.
[5] 常红，陈颖，邢惠娟，等.活血化瘀汤对脑梗死急性期患者颅内血流动力学及血清神经递质的影响[J].陕西中医，2021，42（2）：156-158.
[6] 余勇飞，周瑞，阮清源，等.补阳还五汤合头针丛刺对脑梗死急性期患者脑血管储备功能、血管生长因子水平的影响[J].中国中医急症，2020，29（6）：1008-1010，1019.
[7] 陈俊兰，邓茜婕.自拟化瘀涤痰汤联合依达拉奉治疗急性缺血性脑卒中的疗效观察[J].中国中医急症，2020，29（12）：2165-2168.
[8] 张静静，吕荣祥，刘郁，等.吡拉西坦注射液联合前列地尔对老年出血性脑梗死急性期患者神经功能、血管内皮功能、炎症因子和血液流变学的影响[J].中国老年学杂志，2018，38（10）：2337-2339.
[9] 徐东勋，伍雪英，何佳，等.消栓肠溶胶囊对脑梗死急性期神经功能及PAF、ET、NO的影响[J].中药药理与临床，2016，32（3）：188-190.
[10] 郑筱萸.中药新药临床研究指导原则（试行）[M].北京：中国医药科技出版社，2002：361-362.
[11] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国各类主要脑血管病诊断要点2019[J].中华神经科杂志，2019，52（9）：710-715.
[12] 姜鹏程.灯盏细辛联合依达拉奉治疗急性脑梗死临床研究[J].湖北中医药大学学报，2020，22（4）：55-57.
[13] 唐仕军，赵冬，朱立仓，等.氨基胍对氧-糖剥夺大鼠皮质神经元一氧化氮及半胱氨酸天冬氨酸蛋白酶3表达的影响研究[J].中国全科医学，2016，19（12）：1429-1434.
[14] 陈少銮，李俊达.急性胰腺炎患者ET、NO与NLRP3炎性体的相关性探讨[J].胃肠病学，2019，24（8）：486-488.
[15] 郭慧娟，李仕林，蒋召芹.醒脑活血汤联合头皮针治疗急性脑梗死的疗效及对血液流变学指标影响[J].中国医药导刊，2019，21（11）：674-678.
[16] 李芳芳.注射用丹参多酚酸治疗脑梗死急性期疗效及对Hcy、D-二聚体和hs-CRP水平的影响[J].药物评价研究，2020，43（3）：490-493.
[17] 杨聪，郑刚，齐婧，等.加味真武汤治疗心肾阳虚型甲状腺功能减退性心脏病的临床效果[J].中国医药导报，2020，17（21）：161-164.
[18] 彭冬，秦彬喻，李涵，等.补阳还五汤促进血管新生治疗脑缺血疾病研究进展[J].辽宁中医药大学学报，2020， 22（8）：129-133.
[19] 阮丹丹.益气活血化痰通络汤联合高压氧治疗对急性脑梗死患者血流动力学的影响及疗效分析[J].中华航海医学与高气压医学杂志，2020，27（4）：449-452.
[20] 姜彩霞，陈新祥，白春颖，等.加减星蒌承气汤对脑梗死急性期痰热腑实证患者神经功能的影响[J].中国中医急症，2020，29（3）：460-462.
[21] 陈之兴.化瘀涤痰方对急性脑梗死患者血液流变学及血流动力学的影响[J].中国医学创新，2020，17（18）：73-76.
[22] 肖洪玲，陆松侠，龙子江，等.化瘀涤痰汤对急性硬膜下血肿大鼠脑组织NF-κB介导的炎症反应的影响[J].中药药理与临床，2016，32（2）：169-173.
[23] 王宇，赵珊珊，郑玉敏，等.红花黄色素联合阿加曲班治疗急性脑梗死的疗效及对血清IL8、ET-1、NO水平和血液流变学的影响[J].中西医结合心脑血管病杂志，2018， 16（1）：86-89.
[24] 董国玲，董天勇，张文静，等.通窍化栓汤治疗急性脑梗死（风痰瘀阻型）的临床疗效及对血清ET及NO水平的影响[J].中西医结合心脑血管病杂志，2017，15（8）：988-991.
[25] 王守运，杨言府，鲍远程.加味化痰通络汤对脑梗死急性期风痰阻络证患者血清脑损伤标志物表达及临床疗效影响[J].四川中医，2021，39（1）：129-132.