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| Effect of Gennadol Injection combined with Dexamethasone in the treatment of sudden deafness and its effect on serum ET, sVCAM-1 and AECA levels#br# |
| ZHU Liping1 TAN Xiaoye2▲ KUAI Yebin1 SHAO Binghuan1 |
1.Department of Otolaryngology, Changzhou Maternal and Child Health Hospital, Jiangsu Province, Changzhou 213000, China;
2.Department of Otolaryngology, the First People’s Hospital of Changzhou, Jiangsu Province, Changzhou 213000, China |
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Abstract Objective To investigate the curative effect of Gennadol Injection combined with Dexamethasone in the treatment of sudden deafness and the effects on serum endothelin (ET), soluble vasccular cell adhesion molecule 1 (sVCAM-1) and anti-endothelial cell antibody (AECA). Methods A total of 106 patients with sudden deafness admitted to Changzhou Maternal and Child Health Hospital of Jiangsu Province from June 2018 to April 2021 were selected as the research subjects, and they were divided into study group and control group according to random number table method, with 53 patients in each group. The control group was given Dexamethasone on the basis of conventional treatment, while the research group was given Nandol Injection on the basis of the control group. Both groups maintained administration for one week. Serum ET levels were detected by radioimmunoassay, serum sVCAM-1 and AECA levels were detected by double-antibody sandwich enzyme-linked immunosorbent assay before and three days after treatment, and clinical efficacy, symptom improvement time, and adverse drug reactions were compared between the two groups. Results During the treatment, two cases in the control group dropped out, and finally 51 cases in the control group and 53 cases in the study group were included. After treatment, the expression levels of ET, sVCAM-1, and AECA in serum of two groups were lower than before treatment, and the study group was lower than the control group, the differences were statistically significant (P ＜ 0.05). The clinical efficacy of the study group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05). The symptom improvement time of the study group was shorter than that of the control group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in the incidence of total adverse reactions between the two groups (P ＞ 0.05). Conclusion Treatment of patients with sudden deafness with Gennadol Injection combined with Dexamethasone can shorten the symptom improvement time of patients, effectively reduce the expression levels of ET, sVCAM-1, and AECA in serum of patients, with good clinical efficacy and safety.
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