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| Analysis of children’s tuberculosis in our hospital and the influencing factors of severe tuberculosis#br# |
| XIAO Litao1 XU Minghao2 WANG Yanchun1 ZHUN Tingyan1 LI Quanhong3 YANG Xiaotao1 |
1.Department of Infectious Diseases, Kunming Children’s Hospital, Yunan Province, Kunming 650228, China;
2.Department of Emergency, Kunming Children’s Hospital, Yunan Province, Kunming 650228, China;
3.Department of Pharmacy, Kunming Children’s Hospital, Yunan Province, Kunming 650228, China |
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Abstract Objective To explore the situation of children’s tuberculosis in Kunming Children’s Hospital (hereinafter referred to as “our hospital”) and the influencing factors of severe tuberculosis in order to propose targeted preventive measures to reduce the incidence of the disease. Methods The clinical data of 312 children with tuberculosis admitted to our hospital from January 2016 to December 2020 were collected, and the clinical characteristics of children’s tuberculosis, according to the severity of the disease, they were divided into severe tuberculosis group (87 cases) and non-severe tuberculosis group (225 cases), the influencing factors of severe tuberculosis were analyzed. Results From 2016 to 2020, the number of inpatients with childhood tuberculosis in our hospital has decreased year by year; the clinical manifestations of childhood tuberculosis were mainly fever and cough; the incidence of Tuberculosis in males was more common than that in females, and the incidence was most common in patients aged seven and over, followed by the age group of three to seven years. The incidence of tuberculosis was high in areas with relatively backward economy, serious environmental pollution, dense population and high mobility. The incidence of severe tuberculosis in children was related to age, living environment, tuberculosis contact history, bacille calmette-guerin vaccination history, and nutritional status (P ＜ 0.05). Logistic regression analysis showed that age (OR = 1.918, 95%CI: 1.319-2.642, P = 0.008), living environment (OR = 1.147, 95%CI: 1.096-1.253, P = 0.001), nutritional status (OR = 2.061, 95%CI: 1.437-2.712, P = 0.042), history of tuberculosis exposure (OR = 2.168, 95%CI: 1.413-2.897, P = 0.017) were associated risk factors for severe tuberculosis in children, and bacille calmette-guerin vaccination was a protective factor (OR = 0.887, 95%CI: 0.268-0.953, P = 0.007). Conclusion We should focus on the clinical characteristics of childhood tuberculosis and the high-risk factors that lead to severe tuberculosis, raise awareness, pay close attention to those with high-risk factors, and actively prevent and control tuberculosis, especially severe tuberculosis in children.
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