射血分数中间值的心力衰竭临床研究进展

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Abstract Heart failure (HF) is the terminal stage of heart disease, with high incidence and poor prognosis. In 2016, European Society of Cardiology defined HF with the left ventricular ejection fraction (LVEF) of 40%-49% as the heart failure with mid-range ejection fraction (HFmrEF). This article summarizes the clinical research on HFmrEF finding that ischemic heart disease is one of the most important factors of HFmrEF, combines with atrial fibrillation and hypertension and other diseases, it emphasizes that personalized treatment strategies based on etiology and complications could bring more benefits to patients suffering from HFmrEF. In terms of treatment, traditional drugs, including renin-angiotensin-aldosterone system antagonists, β-receptor blockers, and aldosterone receptor antagonists still have positive effects on HFmrEF; the emerging drug angiotensinreceptor neprilysin enzyme inhibitor has become a recommendation treatment for HFmrEF; some patients with HFmrEF can benefit from Vericiguat and ferric carboxymaltose; sodium-glucose cotransporter 2 inhibitors, and Omecamtiv mecarbil have potential for the treatment of HFmrEF, and they can be used as important research directions in the future. In addition, the changes of LVEF have suggestive effects on the prognosis of HFmrEF.

Key words： Ejection fraction Heart failure Clinical features Treatment

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	SAI Yaoqing LU Shengyu CAO Bangming

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SAI Yaoqing LU Shengyu CAO Bangming. Clinical research progress of heart failure with mid-range ejection fraction#br#[J]. 中国医药导报, 2022, 19(6): 34-38.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I6/34

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