|
|
|
| Analysis on the medication rule and mechanism of Li Enfu in the treatment of chronic atrophic gastritis based on data mining and network pharmacology#br# |
| ZHENG Leilei1 SHA Ying1 LI Huan1 DING Hui2 |
1.The First Clinical Medical College, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Department of Intervention, Shaanxi Institute of Traditional Chinese Medicine, Shaanxi Province, Xi’an 710003, China |
|
|
|
Abstract Objective To analyze the medication rule and mechanism of Li Enfu in the treatment of chronic atrophic gastritis based on data mining. Methods After organizing the prescriptions used in the book One hundred cases of atrophic gastritis cure——Professor Li Enfu’s medical cases and medical treatises, inputed into the traditional Chinese medicine inheritance assistance platform, the association rules were analyzed, and the key drugs were studied by network pharmacology. Results The high-frequency drugs, four nature, five flavors, and channel distribution were obtained, the results of core drugs and combinations, new prescriptions, gene ontology, and Kyoto Gene and Genome Database enrichment analyses were presented. Finally, the medicine-component-target maps were constructed. Conclusion Radix Angelicae Sinensis, Radix Paeoniae Alba, and Rhizoma Ligustici Chuanxiong can act on chronic atrophic gastritis, which can provide reference for clinical use and development of new drug.
|
|
|
|
|
|
[1] 唐仕欢，申丹，卢朋，等.中医传承辅助平台应用评述[J].中华中医药杂志，2015，30（2）：329-331.
[2] Hopkins AL. Network pharmacology [J]. Nat Biotechnol，2007，25：1110-1111.
[3] Hopkins AL. Network pharmacology：The next paradigm in drug discovery [J]. Nat Chem Biol，2008，4（11）：682-690.
[4] De Vries AC，Dan Grieken NC，Looman CW，et al. Gastric Cancer Risk in Patients With Premalignant Gastric Lesions：A Nationwide Cohort Study in the Netherlands [J]. Gastroenterology，2008，134（4）：945-952.
[5] Bosman FT，Carneiro F，Hruban RH，et al. World Health Organization classification of tumors of the digestive system [M]. Lyon：IAR C Press，2010：1-155.
[6] 房静远，杜奕奇，刘文忠，等.中国慢性胃炎共识意见精简版（2017年，上海）[J].上海医学，2017，40（12）：705-708.
[7] 刘静，周易，叶松，等.半夏泻心汤治疗慢性萎缩性胃炎随机对照试验Meta分析[J].辽宁中医药大学学报，2020， 22（9）：195-200.
[8] 王淋，杨慧萍，朱梦佳，等.柴胡疏肝散加减治疗慢性萎缩性胃炎肝胃不和证的Meta分析[J].云南中医学院学报，2020，43（1）：26-33.
[9] 刘伟，潘华峰，王奇，等.健脾益气化瘀解毒法治疗慢性萎缩性胃炎伴癌前病变的系统评价与Meta分析[J].中华中医药杂志，2017，32（11）：5122-5128.
[10] 程若东，赵兵，马尚清，等.益气活血法治疗慢性萎缩性胃炎的Meta分析[J].中华中医药杂志，2017，32（5）：2050-2054.
[11] Zhang H，Jin Z，Cui R，et al. Autoimmune metaplastic atrophic gastritis in chinese：a study of 320 patients at a large tertiary medical center [J]. Scand J Gastroenterol，2017，52（2）：150-156.
[12] 庞鸿茹.萎缩性胃炎治愈案一百例——李恩复教授医案医论集[M].北京：北京科学技术出版社，1993.
[13] 国家药典委员会.中华人民共和国药典[S].一部.北京：中国医药科技出版社，2020.
[14] 苗明三，孙玉信，王晓田.中药大辞典[M].太原：山西科学技术出版社，2017：180.
[15] RU J，LI P，Wang J，et al. TCMSP：a database of systemspharmacology for drug discovery from herbal medicines [J]. J Cheminform，2014，6（1）：13.
[16] 解晶，李丰，石彬彬，等.系统药理学：TCMSP解析中医基础理论研究进展[J].世界中医药，2019，14（10）：2627-2635.
[17] Liu Z，Guo F，Wang Y，et al. BATMAN-TCM：A bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine [J]. Sci Rep，2016（6）：21146.
[18] The UniProt Consortium. UniProt：the universal protein knowledgebase [J]. Nucleic Acids Res，2017，45（D1）：158-169.
[19] Uniprot：a worldwide hub of protein knowledge [J]. Nucleic Acids Res，2019，47（D1）：506-515.
[20] Piero J，Bravo A，Núria QR，et al. DisGeNET：a comprehensive platform integrating information on human disease-associated genes and variants [J]. Nucleic Acids Res，2017，45（D1）：833-839.
[21] Huang DW，Sherman BT，Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources [J]. Nature Protoc，2009，4（1）：44-57.
[22] Huang DW，Sherman BT，Lempicki RA. Bioinformatics enrichment tools：paths toward the comprehensive functional analysis of large gene lists [J]. Nucleic Acids Res，2009，37（1）：1-13.
[23] Shannon P，Markiel A，Ozier O，et al. Cytoscape：A software environment for integrated models of biomolecular interaction networks [J]. Genome Res，2003，13（11）：2498-2504.
[24] 黄远程，朱朝阳，梁怀枫，等.基于数据挖掘的慢性非萎缩性胃炎与慢性萎缩性胃炎用药规律及差异研究[J].中国中医基础医学杂志，2021，27（3）：457-461，471.
[25] 周祯祥，唐德才.中药学[M].北京：中国中医药出版社，2016.
[26] 黄冰雯，李学明，秦韶东.当归芍药胶囊辅助治疗非酒精性脂肪性肝病的效果[J].中国医药科学，2021，11（16）：84-87.
[27] 吕茜倩，曾俊，刘晓东，等.中西医结合治疗干燥综合征合并慢性肾病Ⅲ期1例报道[J].成都医学院学报，2020， 15（4）：542-544.
[28] 王久香.茯苓泽泻汤对肾阴亏虚型2型糖尿病患者糖脂代谢及胰岛细胞功能的影响[J].中国当代医药，2021， 28（6）：139-141.
[29] 高红宁，潘雨柔，殷奕，等.HPLC法测定枳芩颗粒中黄酮类成分的含量[J].中国医药科学，2021，11（1）：79-82.
[30] 陈愉，李梦璇，宋平.基于文献的慢性浅表性胃炎中医证素分布规律研究[J].中国民间疗法，2021，29（9）：97-99. |
|
|
|
