维持性血液透析患者幽门螺杆菌感染情况及其对微炎症、营养状态的影响

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Abstract Objective To investigate Helicobacter Pylori (Hp) infection in maintenance hemodialysis (MHD) patients, and to analyze the relationship between Hp infection and microinflammation and nutritional status. Methods A total of 150 MHD patients treated in the First People’s Hospital of Fuyang District, Hangzhou, Zhejiang Province from January 2019 to December 2020 were selected as the study subjects. The Hp infection was investigated by 14C-Urpa breath test 14C-UBT. Hp positive patients were included in Hp positive group and Hp negative patients were included in Hp negative group. The clinical data and serum hypersensitive C-reactive protein (hs-CRP), albumin (ALB), and prealbumin (PAB) levels were compared between the two groups. Results In this study, 79 of the 150 MHD patients had 14C-UBT≥100 dpm/mol, and the infection rate of Hp was 52.67%, the remaining 71 patients had 14C-UBT ＜ 100 dpm/mol. The dialysis age in Hp positive group was significantly shorter than that in Hp negative group, and the difference was statistically significant (P ＜ 0.05); Hp infection rate in MHD patients with dialysis age ≤1 year, ＞ 1 - 3 years, ＞ 3 - 5 years and ＞ 5 years was 72.22%, 64.70%, 50.00%, and 39.13%, respectively, and the differences were statistically significant (P ＜ 0.05); the levels of ALB and PAB in Hp positive group were significantly lower than those in Hp negative group, and the hs-CRP level was significantly higher than that in Hp negative group, and the differences were statistically significant (P ＜ 0.05). Conclusion Patients with MHD have higher Hp infection rate, while patients with shorter dialysis age have higher Hp infection rate, and MHD patients with Hp infection have more severe microinflammation and malnutrition.

Key words： Maintenance hemodialysis End stage renal disease Helicobacter pylori Innutrition Microinflammation

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	KONG Xiangdong QI Ling XU Jinhua SHAO Guomin

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KONG Xiangdong QI Ling XU Jinhua SHAO Guomin. Infected situation of Helicobacter pylori in maintenance hemodialysis patients and its effect on microinflammation and nutritional status#br#[J]. 中国医药导报, 2022, 19(4): 103-106.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I4/103

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