Influencing factors of the prognosis of COPD complicated with type Ⅱ respiratory failure and the value of serum UA, cTnT, and NT-proBNP levels in predicting the prognosis#br#
CAO Yi JIA Zhenyu
Department of General Medicine, Zhangjiagang Hospital Affiliated to Soochow University, Jiangsu Province, Zhangjiagang 215600, China
Abstract Objective To explore the influencing factors of the prognosis of chronic obstructive pulmonary disease (COPD) complicated with type Ⅱ respiratory failure and the value of serum uric acid (UA), cardiac troponin T (cTnT), and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in prediciting the prognosis. Methods The clinical data of 100 patients with COPD and type Ⅱ respiratory failure admitted to Zhangjiagang Hospital Affiliated to Soochow University from February 2018 to June 2020 were retrospectively analyzed. Patients were divided into good prognosis group (76 cases) and poor prognosis group (24 cases) according to the prognosis. The prognostic factors of COPD patients with type Ⅱ respiratory failure were analyzed, and the predictive value of serum UA, cTnT, and NT-probNP levels for the prognosis of patients were analyzed. Results In the poor prognosis group, 15 patients developed myocardial infarction, three patients developed heart failure, two patients developed multiple organ dysfunction, two patients developed angina pectoris, and two patients died. The acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score, UA, cTnT, NT-probNP, D-dimer, and C-reactive protein levels in the poor prognosis group were higher than those in the good prognosis group, and the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that high APACHE Ⅱ score, and high serum UA, cTnT, and NT-probNP levels were independent risk factors for poor prognosis in COPD patients with type Ⅱ respiratory failure (OR ＞ 1, P ＜ 0.05). The receiver operating characteristic curve of subjects showed that serum UA, cTnT, NT-probNP, and their combination had certain diagnostic value for the prognosis of COPD patients with type Ⅱ respiratory failure (area under the curve＞0.5, P ＜ 0.05). Conclusion Serum UA, cTnT, and NT-probNP in COPD patients with type Ⅱ respiratory failure are correlated with prognosis, and the three have certain diagnostic value of prognosis alone or in combination.
CAO Yi JIA Zhenyu. Influencing factors of the prognosis of COPD complicated with type Ⅱ respiratory failure and the value of serum UA, cTnT, and NT-proBNP levels in predicting the prognosis#br#[J]. 中国医药导报, 2022, 19(4): 95-98.
