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| Intervention effect of tetrandrine on radiation pneumonia and its influence on transforming growth factor-β1 and interleukin-6#br# |
| ZHU Nuo XIAO Wei▲ YANG Jiu |
| Department of Radiotherapy, Nanjing Chest Hospital Affiliated Brain Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029, China |
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Abstract Objective To investigate the intervention effect of tetrandrine on radiation pneumonia and its influence on transforming growth factor-β1 (TGF-β1) and interleukin-6 (IL-6). Methods A total of 75 radiation pneumonia patients admitted to Nanjing Chest Hospital from June 2017 to December 2020 were selected as the research subjects. They were divided into the control group (37 cases) and the test group (38 cases) by random number table method, and the control group was given conventional treatment, the experimental group was given oral tetrandrine on the basis of conventional treatment, both groups were treated for two weeks. Vital capacity (VC), forced expiratory volume in the first second (FEV1), TGF-β1 and IL-6 levels were compared before and after treatment. Results After treatment, the total effective rate of experimental group was higher than that in the control group (P ＜ 0.05). After treatment, VC and FEV1 in the two groups were higher than those before treatment, TGF-β1 and IL-6 in the two groups were lower than those before treatment, and VC and FEV1 in the experimental group were higher than those in the control group, TGF-β1 and IL-6 in the experimental group were lower than those in the control group (P ＜ 0.05). There were no obvious drug-related adverse reactions in the both groups. Conclusion Tetrandrine can improve the symptoms of radiation pneumonia and reduce the inflammation reation caused by radiotherapy.
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