针刺联合温脾通络开窍汤治疗痰浊阻窍型血管性痴呆的效果

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Abstract Objective To explore the effect of acupuncture combined with Wenpi Tongluo Kaiqiao Decoction in the treatment of vascular dementia (VD) with syndrome of phlegm turbidity obstructing the orifices. Methods A total of 113 VD patients with syndrome of phlegm turbidity obstructing the orifices admitted to Fuxin Mine General Hospital of Liaoning Health Industry Group from January 2018 to March 2021 were selected as the research subjects. According to the random number table method, the patients were divided into control group (56 cases) and experimental group (57 cases). The control group was treated with conventional Western medicine and acupuncture, and the experimental group was treated with Wenpi Tongluo Kaiqiao Decoction on the basis of the control group, both groups were treated for 12 weeks. The clinical efficacy, traditional Chinese medicine syndrome score, mini-mental state examination (MMSE) scale, Hasegawa dementia scale (HDS), activities of daily living (ADL) scale, interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and tumor necrosis factor-α (TNF-α) in the two groups were compared, the incidence of adverse reactions were observed. Results After treatment, the total effective rate of the experimental group was higher than that in the control group (P ＜ 0.05). After treatment, the headache with binding sensation score, hypophrenia score, anorexia and abdominal distension score, silence score, slow movement score, and vomiting score in the two groups were decreased, which in the experimental group were lower than those in the control group (P ＜ 0.05). After treatment, the MMSE, HDS, and ADL scores in the two groups were increased, which in the experimental group were higher than those in the control group (P < 0.05). After treatment, the levels of serum IL-6 and TNF-α in the two groups were decreased, and which in the experimental group were lower than those in the control group (P ＜ 0.05), the VEGF levels in the two groups were increased, which in the experimental group was higher than that in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions in the two groups (P ＞ 0.05). Conclusion Acupuncture combined with Wenpi Tongluo Kaiqiao Decoction in the treatment of VD patients with syndrome of phlegm turbidity obstructing the orifices can rapidly improve the clinical symptoms, has definite curative effect, can reduce inflammatory factors, improve the ability of life, cognitive function and neurological function.

Key words： Wenpi Tongluo Kaiqiao Decoction Acupuncture Vascular dementia Clinical effect

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	GUO Zheng1 SHI Bin2
	3 WANG Cong’an2 WANG Yang1 ZHOU Jiahui1

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GUO Zheng1 SHI Bin2,3 WANG Cong’an2 WANG Yang1 ZHOU Jiahui1. Effect of acupuncture combined with Wenpi Tongluo Kaiqiao Decoction in the treatment of vascular dementia with syndrome of phlegm turbidity obstructing the orifices#br#[J]. 中国医药导报, 2021, 18(35): 158-162.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I35/158

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