恩替卡韦、富马酸替诺福韦二吡夫酯片治疗慢性乙型肝炎及其肝硬化的效果比较

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Abstract Objective To compare and analyze the effects of Entecavir and Tenofovir Disoproxil Fumarate in the treatment of chronic hepatitis B and liver cirrhosis patients. Methods A retrospective selection of 109 patients with chronic hepatitis B and liver cirrhosis admitted to Jilin Province Faw General Hospital from December 2018 to December 2020, they were divided into Entecavir (ETV） group (55 cases) and Tenofovir Disoproxil Fumarate (TDF) group (54 ceses) according to their treatment methods. Blood calcium (Ca), blood phosphorus (P), estimated glomerular filtration rate (eGFR) and bone mineral density (BMD) were collected before treatment (T0), 24 weeks after treatment (T1), 48 weeks after treatment (T2), and 96 weeks after treatment (T3), and the clinical significance of changes in Ca, P, eGFR and BMD were analyzed and compared. Results The time point difference of Ca between the two groups was statistically significant (P ＜ 0.05). There was no significant difference in P at time point, between groups and interaction (P ＞ 0.05). The time point and interaction of eGFR showed statistically significant differences (P ＜ 0.05), but there was no statistically significant difference between groups (P ＜ 0.05). Further pairwise comparison, intra-group comparison: Ca decreased at T3 compared with T0, and eGFR decreased at T1, T2, and T3 in TDF group compared with T0, with statistical significances (P ＜ 0.05). The time comparison of femoral neck bone mineral density and lumbar vertebra bone mineral density between the two groups had statistical significances (P ＜ 0.05). Further pairwise comparison showed that lumbar bone mineral density in TDF group was lower than that in ETV group at T2 and T3, with statistical significances (P ＜ 0.05). Conclusion ETV and TDF in the treatment of patients with hepatitis B and cirrhosis of the liver, the two drugs is not obvious effect on Ca, P, patients with the extension of treatment time of TDF affect the eGFR, TDF bone mineral density of patients treated by TDF is higher than ETV, and both the mean bone density decrease, as the treatment time extended effect is not obvious, and provide the basis for clinical doctor standard antiviral treatment for a long time.

Key words： Entecavir Tenofovir Disoproxil Fumarate Chronic hepatitis B Hepatitis B cirrhosis Blood calcium Blood phosphorus Estimated glomerular filtration rate Bone mineral density

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	FU Guangshuang SHEN Enhua WANG Moli LI Xinshan YUAN Yimeng WU Yang

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FU Guangshuang SHEN Enhua WANG Moli LI Xinshan YUAN Yimeng WU Yang. Effect comparison of Entecavir and Tenofovir Disoproxil Fumarate in the treatment of chronic hepatitis B and liver cirrhosis#br#[J]. 中国医药导报, 2021, 18(35): 121-124.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I35/121

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