3D打印模板较单纯CT引导125I粒子植入头颈部复发转移癌优势研究

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Abstract Objective To investigate the advantages of 3D printing template compared with simple CT-guided 125I seeds implantation in recurrent and metastatic cancer of head and neck. Methods A total of 99 patients (99 lesions) with recurrent and metastatic cancer of head and neck treated with 125I seeds in Hebei General Hospital from April 2015 to February 2019 were selected, according to whether 3D printing template was applied, they were divided into 3D printing template group (group A, 49 cases [49 lesions]) and simple CT guided group (group B, 50 cases [50 lesions]). The quality and efficacy of 125I seeds implantation were evaluated between two groups; CT scan times, operation time and single seed implantation time were compared between two groups; the target volume, seeds number and dosimetric parameters (D90, V90, V100, V150) before and after operation were compared between two groups; the incidence of complications in two groups were observed. Results There was no significant difference in the quality of 125I seeds implantation between two groups (P > 0.05). Two months after operation, there were no significant differences in local control rate and effective rate between two groups (P > 0.05). Three months after operation, there was no significant difference in local control rate between two groups (P > 0.05); the effective rate of group A was higher than that of group B, and the difference was statistically significant (P < 0.05). The operation time and single seed implantation time of group A were shorter than those of group B, and CT scan times were less than those of group B, and the differences were statistically significant (P < 0.05). There were no significant differences in target volume, seeds number, and dosimetric parameters in group A before and after operation (P > 0.05). There were no significant differences in target volume, seeds number, D90, and V90 in group B before and after operation (P > 0.05); after operation, V100 in group B was lower than that before operation, and V150 was higher than that before operation, and the differences were statistically significant (P < 0.05). After operation, there were no significant differences in target volume, seeds number, D90, V90, and V150 between two groups (P > 0.05); V100 in group A was higher than that in group B, and the differences were statistically significant (P < 0.05). The incidence of puncture pain in group A was lower than that in group B, and the difference was statistically significant (P < 0.05); there was no significant difference in the incidence of hoarseness between two groups (P > 0.05). Conclusion Compared with simple CT guidance, 3D printing template can shorten the operation time, reduce the number of scans, reduce the incidence of complications, and improve the efficacy to a certain extent.

Key words： 3D printing 125I seeds Head and neck neoplasms Comparative study

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	WANG Zeyang LIANG Yansong ZHANG Hongtao CAO Guohui LIU Zezhou GAO Zhen ZHAO Jinxin WANG Juan

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WANG Zeyang LIANG Yansong ZHANG Hongtao CAO Guohui LIU Zezhou GAO Zhen ZHAO Jinxin WANG Juan. Research on the advantages of 3D printing template compared with simple CT-guided 125I seeds implantation in recurrent and metastatic cancer of head and neck#br#[J]. 中国医药导报, 2021, 18(35): 105-109.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I35/105

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