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| Effect of Yishen Zhuyu Decoction combined with Leuprolide Acetate Microspheres in the treatment of endometriosis with kidney deficiency and phlegm stasis #br# |
| CHEN Jingxian1 LIN Haipeng2 LIANG Xuefang3 WANG Yongxia3 TAN Xixi4 |
1.Department of Obstetrics and Gynecology, Yangjiang Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Guangdong Province, Yangjiang 529500, China;
2.Ward Two, Department of Internal Medicine, People’s Hospital of Yangjiang Affiliated to Guangdong Medical University, Guangdong Province, Yangjiang 529500, China;
3.Department of Gynecology, Traditional Chinese Medicine Hospital of Guangdong Province, Guangdong Province, Guangzhou 510000, China;
4.Department of Medicine, People’s Hospital of Yangjiang Affiliated to Guangzhou Medical University, Guangdong Province, Yangjiang 529500, China |
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Abstract Objective To analyze the clinical effect of Yishen Zhuyu Decoction combined with Leuprorelin Acetate Microspheres in the treatment of endometriosis (EMT) of kidney deficiency and phlegm stasis. Methods From June 2018 to June 2020, 80 patients with EMT treated in Yangjiang Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine were selected as the research objects, according to random number table method, they were divided into two groups, with 40 cases in each group. The control group was treated with Leuprorelin Acetate Microspheres, and the study group was treated with Yishen Zhuyu Decoction on the basis of control group. The clinical efficacy, the levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) before and after treatment and the occurrence of adverse reactions in two groups were observed and recorded. Results The clinical effect of study group was better than that of control group (P < 0.05). After treatment, MMP-9 levels between two groups were lower than those before treatment, and TIMP-1 levels between two groups were higher than those before treatment (P < 0.05); MMP-9 level in study group was lower than that in control group, and TIMP-1 level was higher than that in control group (P < 0.05). The total incidence of adverse reactions in study group was lower than that in control group (P < 0.05). Conclusion The application of Yishen Zhuyu Decoction combined with Leuprorelin Acetate Microspheres in EMT is helpful to improve the therapeutic effect, regulate the levels of TIMP-1 and MMP-9 and reduce adverse reactions.
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