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| Study on the medication law of traditional Chinese medicine in the treatment of membranous nephropathy based on data mining#br# |
| WANG Rumeng ZHAO Mingming YU Yi CHANG Meiying MA Sijia ZHANG Yu |
| Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China |
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Abstract Objective To explore the medication law of traditional Chinese medicine in the treatment of membranous nephropathy. Methods Periodical literatures collected by CNKI were used as data sources. The literature studies about traditional Chinese medicine in the treatment of membranous nephropathy from January 2000 to September 2020 were collected and summarized. Excel 2013, SPSS Modeler 18.0 and SPSS Statistics 21.0 software were used, and the frequency of drug use, nature and flavour, channel tropism, related association rule and clustering results were used as observation indexes for statistical analysis. Results Through screening, 72 formulas and 116 kinds of herbs were obtained. Among them, 26 herbs were used at least 10 times, four nature of drugs were mainly warm, cold and calm, five flavours were mainly sweet, bitter and spicy, the mainly meridians were kidney meridian, lung meridian, spleen meridian and liver meridian. Radix Astragali seu Hedysari, Poria, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis were commonly used. Four cluster formulas were obtained by high-frequency drug clustering, which showed that traditional Chinese medicine in the treatment of membranous nephropathy by using the therapies of dissipating wind and unblocking collaterals, activating blood and resolving stasis, resolving dampness and disinhibiting water, clearing heat and removing toxin, and others on the basis of tonifying spleen and kidney to syndrome differentiation. Conclusion Traditional Chinese medicine in the treatment of membranous nephropathy follows the pathogenesis nature of “root deficiency and manifestation excess”. Medications should pay attention to the application of both warming and clearing therapies, reinforcing and reducing. Kidney, lung and spleen are regulated simultaneously and paid attention, and other organs are gave consideration. The summary of the characteristics of modern doctors in the treatment of membranous nephropathy has reference significance for the clinical treatment of membranous nephropathy.
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