健脾清热升降方联合西药治疗反流性食管炎的效果

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Abstract Objective To investigate the effect of Jianpi Qingre Shengjiang Decoction combined with Western medicine on reflux esophagitis. Methods A total of 80 cases of reflux esophagitis patients with syndrome of qi inversion in middle deficiency admitted to Anhui Wuhu Chinese Medicine Hospital from April 2019 to July 2020 were selected and divided into combined group and control group according to random number table method, with 40 cases in each group. The control group was treated with conventional Western medicine, and the combined group was treated with Jianpi Qingre Shengjiang Decoction combined with Western medicine. Both groups were treated for eight weeks. Traditional Chinese medicine symptom score, clinical efficacy, serum gastrin (GAS) and plasma pepsin (PG) Ⅰ and Ⅱ levels and adverse reactions were compared between the two groups. Results There was no significant difference in traditional Chinese medicine symptom score between the two groups before treatment (P ＞ 0.05). After treatment, the scores of traditional Chinese medicine symptoms in both groups were higher than those before treatment, and the combined group was higher than the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the total effective rate of combined group was higher than that of control group, the difference was statistically significant (P ＜ 0.05). There were no significant differences in serum GAS and plasma PG Ⅰ and PG Ⅱ levels between the two groups before treatment (P ＞ 0.05). After treatment, the levels of serum GAS and plasma PG Ⅰ in both groups were higher than those before treatment, and those in the combined group were higher than those in the control group. The levels of plasma PG Ⅱ in both groups were lower than those before treatment, and those in the combined group were lower than those in the control group, with statistical significances (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion The combination of Jianpi Qingre Shengjiang Decoction combined with Western medicine in the treatment of reflux esophagitis can improve the clinical symptoms, with definite curative effect, and improve serum GAS and plasma PG levels, which is safe and reliable.

Key words： Jianpi Qingre Shengjiang Decoction Western medicine Syndrome of qi inversion in middle deficiency Reflux esophagitis Gastrin Pepsin

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	SHENG Zhenxing1 WANG Yizhou2 REN Lijun3▲

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SHENG Zhenxing1 WANG Yizhou2 REN Lijun3▲. Effect of Jianpi Qingre Shengjiang Decoction combined with Western medicine on reflux esophagitis#br#[J]. 中国医药导报, 2021, 18(33): 135-138.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I33/135

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