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| Clinical effect of Liyan Kaiyin Decoction combined with conventional Western medicine in the treatment of vocal cord leukoplakia#br# |
| AN Jingjuan WU Kunmin▲ LI Zeqing ZHU Chunhui YANG Qi SHEN Jie FEI Youpeng WANG Lirong |
| Department of Otolaryngology, Jiangsu Second Hospital of Traditional Chinese Medicine the Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210000, China |
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Abstract Objective To evaluate the clinical efficacy of Liyan Kaiyin Decoction in the treatment of vocal cord leukoplakia. Methods A total of 69 patients with vocal cord leukoplakia admitted to the Jiangsu Second Hospital of Traditional Chinese Medicine from March 2017 to October 2019 were selected as the research objects. They were divided into study group (35 cases) and control group (34 cases) by random number table method. The control group received conventional Western medicine treatment, the study group received conventional Western medicine combined with Liyan Kaiyin Decoction treatment, and computer voice objective analysis was carried out. Objective voice, such as fundamental frequency perturbation (Jitter), amplitude perturbation (Shimmer), pitch perturbation quotient (PPQ), noise-to-harmonic ratio (NHR) and maximum phonation time (MPT), typing of intraepithelial papillary capillary loops (IPCL), clinical efficacy and adverse events were observed in two groups. Results After treatment, the effective rate of study group was higher than that of control group (P ＜ 0.05). After treatment, there was a statistically significant difference in IPCL typing between the two groups (P ＜ 0.05). After treatment, Jitter, Shimmer, PPQ, NHR, and MPT in the two groups decreased compared with before treatment, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). The incidence of adverse events in the study group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Liyan Kaiyin Decoction is effective in treating vocal cord leukoplakia and improving voice after objective voice evaluation.
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