lncRNAs用于诊断2型糖尿病的meta分析

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Abstract Objective To systematically evaluate the diagnostic value of long noncoding RNA (lncRNA) in type 2 diabetes by meta analysis. Methods PubMed, Embase, Cochrane Library, CNKI, Wanfang Data, and VIP were searched by computer, and clinical studies on lncRNAs in the diagnosis of type 2 diabetes mellitus published from inception to February 2021 were collected for screening, data extraction, and literature quality assessment. Meta-analysis was performed on the included studies by using Meta-disc 1.4 and Stata 16 software. Results A total of 12 studies were included, including 1776 patients with type 2 diabetes mellitus and 1508 healthy subjects. Meta-analysis results showed that the combination sensitivity was 0.75(95%CI: 0.73-0.77, P ＜ 0.001), the combination specificity was 0.70(95%CI: 0.67-0.72, P ＜ 0.001), and the area under the summary receiver operating characteristic curve was 0.79, Q* = 0.73. Subgroup analysis showed that the selection of lncRNAs with different variation trends was the source of heterogeneity in the diagnosis of type 2 diabetes mellitus (P ＜ 0.05). Sensitivity analysis results showed that the combined diagnostic odds ratio was 7.93 to 9.75 after the exclusion of literatures one by one, indicating that the included literatures had good stability. The results of publication bias analysis showed that there was no significant publication bias among the studies (P ＞ 0.05). Conclusion The expression level of circulating lncRNAs has important value and significance for the early diagnosis of type 2 diabetes mellitus.

Key words： Long noncoding RNA Type 2 diabetes mellitus Meta analysis Diagnosis Biomarker

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	TAN Xiaoyong1 ZHAO Jichang2 TIAN Mingying3 ZHAO Enhui3 ZHU Mei3 XING Yong1 RAN Qijun4

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TAN Xiaoyong1 ZHAO Jichang2 TIAN Mingying3 ZHAO Enhui3 ZHU Mei3 XING Yong1 RAN Qijun4. Meta-analysis of lncRNAs for diagnosis of type 2 diabetes mellitus#br#[J]. 中国医药导报, 2021, 18(33): 80-85.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I33/80

[1] Roden M，Shulman GI. The integrative biology of type 2 diabetes [J]. Nature，2019，576（7785）：51-60.
[2] Aydin ?魻，Nieuwdorp M，Gerdes V. The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes [J]. Curr Diab Rep ，2018，18（8）：55.
[3] Li Y，Ren K. The Mechanism of Contrast-Induced Acute Kidney Injury and Its Association with Diabetes Mellitus [J]. Contrast Media Mol Imaging，2020，2020：3295176.
[4] Kader ZA，Mahomed O. Prevalence and risk factors associated with diabetes retinopathy amongst type Ⅱ diabetes mellitus at a primary care vision clinic in the eThekwini District，KwaZulu-Natal in 2017 [J]. African Vision and Eye Health，2020，79（1）：a556.
[5] Edmonds M，Manu C，Vas P. The current burden of diabetic foot disease [J]. J Clin Orthop Trauma，2021，17：88-93.
[6] Prentki M，Nolan CJ. Islet beta cell failure in type 2 diabetes [J]. J Clin Invest，2006，116（7）：1802-1812.
[7] Yan Y，Xu Z，Li Z，et al. An Insight into the Increasing Role of LncRNAs in the Pathogenesis of Gliomas [J]. Front Mol Neurosci，2017，10：53.
[8] Lu Y，Meng X，Wang L，et al. Analysis of long non-coding RNA expression profiles identifies functional lncRNAs associated with the progression of acute coronary syndromes [J]. Exp Ther Med，2018，15（2）：1376-1384.
[9] Zhang EB，Han L，Yin DD，et al. c-Myc-induced，long，noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer [J]. Med Oncol，2014，31（5）：914.
[10] Liu D，Yu X，Wang S，et al. The gain and loss of long noncoding RNA associated-competing endogenous RNAs in prostate cancer [J]. Oncotarget，2016，7（35）：57228-57238.
[11] Yin Q，Wu A，Liu M. Plasma Long Non-Coding RNA（lncRNA）GAS5 is a New Biomarker for Coronary Artery Disease [J]. Med Sci Monit，2017，12（23）：6042-6048.
[12] Wang L，Su N，Zhang Y，et al. Clinical Significance of Serum lncRNA Cancer Susceptibility Candidate 2（CASC2）for Chronic Renal Failure in Patients with Type 2 Diabetes [J]. Med Sci Monit，2018，9（24）：6079-6084.
[13] Carter G，Miladinovic B，Patel AA，et al. Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus [J]. BBA Clin，2015，4：102-107.
[14] Li X，Zhao Z，Gao C，et al. The Diagnostic Value of Whole Blood lncRNA ENST00000550337.1 for Pre-Diabetes and Type 2 Diabetes Mellitus [J]. Exp Clin Endocrinol Diabetes，2017，125（6）：377-383.
[15] Mansoori Z，Ghaedi H，Sadatamini M，et al. Downregulation of long non-coding RNAs LINC00523 and LINC00994 in type 2 diabetes in an Iranian cohort [J]. Mol Biol Rep，2018，45（5）：1227-1233.
[16] Saeidi L，Ghaedi H，Sadatamini M，et al. Long non-coding RNA LY86-AS1 and HCG27_201 expression in type 2 diabetes mellitus [J]. Mol Biol Rep，2018，45（6）：2601-2608.
[17] Erfanian Omidvar M，Ghaedi H，Kazerouni F，et al. Clinical significance of long noncoding RNA VIM-AS1 and CTBP1-AS2 expression in type 2 diabetes[J]. J Cell Biochem，2019，120（6）：9315-9323.Epub，2018.
[18] 李一卉，孙璐，戴程婷，等.长链非编码RNA TUG1/MALAT1在2型糖尿病患者外周血单个核细胞中的表达[J].南京医科大学学报：自然科学版，2019，39（4）：534-538.
[19] Ma Q，Wang L，Yang Y，et al. Association between lncRNA and GCKR gene in type 2 diabetes mellitus [J]. Clin Chim Acta，2020，501：66-71.
[20] Saleh AA，Kasem HE，Zahran ES，et al. Cell-free long non-coding RNAs（LY86-AS1 & HCG27_201and GAS5）as biomarkers for pre-diabetes and type 2 DM in Egypt [J]. Biochem Biophys Rep，2020，23：100770.
[21] 黄少华.lncRNA MEG3在2型糖尿病患者血浆中的表达及意义[D].沈阳：中国医科大学，2020.
[22] Kazerouni F，Bayani A，Asadi F，et al. Type2 diabetes mellitus prediction using data mining algorithms based on the long-noncoding RNAs expression：a comparison of four data mining approaches [J]. BMC Bioinformatics，2020，21（1）：372.
[23] Morán I，Akerman I，van de Bunt M，et al. Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific，dynamically regulated，and abnormally expressed in type 2 diabetes [J]. Cell Metab，2012，16（4）：435-448.
[24] Nica AC，Ongen H，Irminger JC，et al. Cell-type，allelic，and genetic signatures in the human pancreatic beta cell transcriptome [J]. Genome Res，2013，23（9）：1554-1562.
[25] Bramswig NC，Everett LJ，Schug J，et al. Epigenomic plasticity enables human pancreatic α to β cell reprogramming [J]. J Clin Invest，2013，123（3）：1275-1284.
[26] Jie R，Zhu P，Zhong J，et al. LncRNA KCNQ1OT1 affects cell proliferation，apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF-κB pathway in diabetic nephropathy [J]. Diabetol Metab Syndr，2020，12（1）：77.
[27] Ding GL，Wang FF，Shu J，et al. Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia [J]. Diabetes，2012，61（5）：1133-1142.
[28] Ke N，Pi LH，Liu Q，et al. Long noncoding RNA SNHG7 inhibits high glucose-induced human retinal endothelial cells angiogenesis by regulating miR-543/SIRT1 axis [J]. Biochem Biophys Res Commun，2019，514（2）：503-509.