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| Mechanism of pyroptosis and its role in various kidney diseases#br# |
| SUN Xiaoyi1 JIANG Yuqin1 TANG Yuyan2 LIU Hejing1 LU Xun3 WEI Minggang2 |
1.Department of Nephrology, the First Affiliated Hospital of Soochow University, Jiangsu Province, Suzhou 215006, China;
2.Department of Traditional Chinese Medicine, the First Affiliated Hospital of Soochow University, Jiangsu Province, Suzhou 215006, China;
3.Department of Traditional Chinese Medicine, North District, Suzhou Municipal Hospital, Jiangsu Province, Suzhou 215000, China |
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Abstract Pyroptosis is a newly discovered method of pro-inflammatory programmed cell death in recent years, which can be caused by inflammasome, caspase-1, human caspase-4/5, and mouse caspase- 11, and its downstream response factor gasdermin D (GSDMD) co-mediated. When the body is invaded by foreign substances, it can initiate the upstream reaction element of pyroptosis, which promotes the structural change of GSDMD. After more GSDMD N-terminal necrotic domains accumulate to form a membrane pore-forming active substance that causes cell membrane damage and causes inflammatory factors, such as interleukin-18 (IL-18) and IL-1β are released to cause inflammation. The mechanism of pyroptosis is involved in crystal-related nephropathy, ischemia-reperfusion kidney injury, diabetic nephropathy, and renal fibrosis. This article will review the specific mechanism of pyroptosis and its role in the occurrence and development of a variety of kidney diseases.
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