|
|
Progress in the treatment of polycystic ovary syndrome with spleen deficiency and phlegm dampness and insulin resistance#br# |
QU Yunqing1 FENG Xiaoling2 HAN Zhiyu1 |
1.Graduate School, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Department of Gynaecology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
|
|
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, moreover, insulin resistance (IR) plays a key role in the development of metabolic dysfunction, is the basis of obesity-related diseases such as PCOS. By optimizing your lifestyle and habits or taking drugs like Metformin, PCOS can be significantly improved, and IR can also be reversed to a large extent. According to Chinese medicine, PCOS belongs to the category of “late menstruation” and “amenorrhea”. It is caused by spleen deficiency and phlegm dampness. Invigorating the spleen and regulating qi, transporting phlegm and dampness. This paper reviews the progress of the treatment of spleen deficiency and phlegm dampness PCOS-IR by combining traditional Chinese medicine with Western medicine, in order to provide reference for clinical diagnosis and treatment.
|
|
|
|
|
[1] Macklon NS. Polycystic ovary syndrome [J]. BMJ,2011, 343:d6407.
[2] Willams T,Mortada R,Porter S. Diagnosis and treatment of polycystic ovary syndrome [J]. Am Fam Physician,2016, 94:106-113.
[3] 王婧,马舒婷,张跃辉.线粒体功能受损与多囊卵巢综合征发生胰岛素抵抗相关性的研究进展[J].中国医药导报,2021,18(6):42-45.
[4] 董金凤,蒋晶,郑彤彤,等.胰岛素抵抗肥胖及性激素水平与多囊卵巢综合征患者血清抗苗勒管激素水平的相关性[J].中国妇幼保健,2021,36(9):2086-2089.
[5] Brown E,Wilding JPH,Barber TM,et al. Weight loss variability with SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes mellitus and obesity:Mechanistic possibilities [J]. Obes Rev,2019,20(6):816-828.
[6] Borghouts LB,Keizer HA. Exercise and insulin sensitivity:A review [J]. Int J Sports Med,2000,21(1):1-12.
[7] Marson EC,Delevatti RS,Prado AK,et al. Effects of aerobic,resistance,and combined exercise training on insulin resistance markers in overweight or obese children and adolescents:A systematic review and meta-analysis [J]. Prev Med,2016,93,211-218.
[8] Motahari-Tabari N,Ahmad Shirvani M,Shirzad E,et al. The effect of 8 weeks aerobic exercise on insulin resistance in type 2 diabetes:A randomized clinical trial [J]. Glob J Health Sci,2014,7(1):115-121.
[9] Fujita H,Hosono A,Shibata K,et al. Physical Activity Earlier in Life Is Inversely Associated with Insulin Resistance Among Adults in Japan [J]. J Epidemiol,2019,29(2):57-60.
[10] Thomas M,Ioannis K,Harpal S,et al. Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction [J]. Int J Mol Sci,2021,22:546-562.
[11] Castro Q,Flores G,Nunez O,et al. Dietary Carbohydrates and Insulin Resistance in Adolescents from Marginalized Areas of Chiapas,Mexico [J]. Nutrients,2019,11(12):3066.
[12] Donga E,Romijn J. Sleep characteristics and insulin sensitivity in humans[J]. Handb Clin Neurol,2014,124: 107-114.
[13] Van D,Balkau B,Segrestin B,et al. Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study [J]. Diabetes Metab,2019,45(4):375-381.
[14] 夏佳,钟敏,张新霞.基于肠道菌群探讨多囊卵巢综合征的中医药治疗[J].湖北中医杂志,2021,43(4):62-66.
[15] Shpakov A. Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms [J]. Pharmaceuticals,2021,14:42.
[16] 樊燕飞.达英-35联合二甲双胍对多囊卵巢综合征患者胰岛素抵抗状态及排卵功能的影响[J].当代医学,2021,27(12):177-178.
[17] Gadalla M,Norman R,Tay C,et al. Medical and Surgical Treatment of Reproductive Outcomes in Polycystic Ovary Syndrome:An Overview of Systematic Reviews [J]. Int J Fertil Steril,2020,13:257-270.
[18] L?覬vvik T,Carlsen S,Salvesen ?覫,et al. Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2):A randomised,double-blind,placebo-controlled trial [J]. Lancet Diabetes Endocrinol,2019,7(4):256-266.
[19] Sinai T,Tang T,Yasmin E. Role of Metformin in Women’s Health:Review of Its Current Place in Clinical Practice and Emerging Indications for Future [J]. Obstet Gynecol Surv,2016,71(5):307-317.
[20] Sharpe A,Morley L,Tang T,et al. Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome [J]. Cochrane Database Syst Rev,2019,12:CD013505.
[21] Kollmann M,Martins W,Lima M,et al. Strategies for improving outcome of assisted reproduction in women with polycystic ovary syndrome:Systematic review and meta-analysis [J]. Ultrasound Obstet Gynecol,2016,48(6):709-718.
[22] Palomba S,Falbo A,La Sala G. Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles:A systematic review and meta-analysis of randomised controlled trials [J]. BJOG,2013, 120(3):267-276.
[23] Nemati M,Nemati S,Taheri A. Comparison of metformin and N-acetyl cysteine,as an adjuvant to clomiphene citrate,in clomiphene-resistant women with polycystic ovary syndrome [J]. J. Gynecol Obstet Hum Reprod,2017, 46(7):579-585.
[24] Tang T,Lord J,Norman R,et al. Insulin-sensitising drugs (metformin,rosiglitazone,pioglitazone,D-chiro-inositol) for women with polycystic ovary syndrome,oligo amenorrhoea and subfertility [J]. Cochrane Database Syst Rev,2012,5:CD003053.
[25] Rezk M,Shaheen A,Saif E. Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome:A randomized clinical trial [J]. Gynecol Endocrinol,2018, 34(4):298-300.
[26] Bjelica A,Trnini'c-Pjeri■ A,Mladenovi■-Segedi L,et al. Comparison of the efficiency of clomiphene citrate and letrozole in combination with metformin in moderately obese clomiphene citrate-resistant polycystic ovarian syndrome patients [J]. Srp Arh Celok Lek,2016,144(3/4):146-150.
[27] Jensterle M,Kravos N,Gori■ar K,et al. Short-term effectiveness of low dose liraglutide in combination with metformin versus high dose liraglutide alone in treatment of obese PCOS:Randomized trial [J]. BMC Endocr Disord,2017,17:5.
[28] Livadas S,Androulakis I,Angelopoulos N,et al. Liraglutide administration improves hormonal/metabolic profile and reproductive features in women with HAIR-AN syndrome [J]. Endocrinol Diabetes Metab Case Rep,2020, 2020:19-0150.
[29] 张美微,侯丽辉,刘颖华.中医药治疗多囊卵巢综合征胰岛素抵抗的研究进展[J].世界中西医结合杂志,2016, 11(3):436-438.
[30] 谢蓬蓬,曾蕾,余璟玮,等.加减苍附导痰汤对多囊卵巢综合征脾虚痰湿证代谢和受孕情况的影响研究[J/OL].中国实验方剂学杂志:1-10[2021-05-12]. https://doi.org/10.13422/j.cnki.syfjx.20210532.
[31] 杨玉彬,陈树清,秦鉴,等.健脾化痰方联合热量控制对肥胖型多囊卵巢综合征患者的治疗效果研究[J].中国全科医学,2015,18(31):3864-3867,3871.
[32] 石相应,顾江红.温肾健脾化痰法对痰湿型多囊卵巢综合征患者胰岛素抵抗及血清性激素水平的影响[J].中国性科学,2019,28(10):89-93.
[33] 陈叶.赵恒侠教授从脾虚痰湿论治多囊卵巢综合征[J].现代中西医结合杂志,2019,28(10):1079-1081. |
|
|
|