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New advances in cognitive impairment associated with depressive disorder and its evaluation#br# |
HAO Wensi1 WEI Min1 LIU Jianghong1 SONG Penghui1 WANG Jing2 WANG Yuping1 |
1.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
2.School of Basic Medical, Capital Medical University, Beijing 100069, China |
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Abstract Depressive disorder is a common mental disorder characterized by emotional symptoms, such as low mood, slow thinking, and decreased will activity. More and more evidences indicate that the cognitive impairment in patients with depressive disorder is mainly related to the impairment of the frontal parietal cognitive control network. Of these, executive function, memory, and attention are the most commonly affected areas and can be assessed by specific neuropsychological tests. Executive function can be evaluated by trail making test part B, Stroop color-word test, etc. Memory is assessed by Wechsler memory scale and Rey auditory verbal learning test, and attention is assessed by continuous performance test, Delis-Kaplan executive function system test, CogitEx Ⅱ. At present, there are new comprehensive assessment methods for the cognitive function of patients with depressive disorder, such as THINC-it, severe cognitive impairment profile, cognitive component of rating bipolar disorder. A more detailed assessment of specific areas of cognitive impairment in patients with depressive disorders will improve the accuracy of screening and diagnosis, and have great implications for molecular studies and future targeted therapies.
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