|
|
|
| Effect of Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets on bone mineral density, estradiol and immune function in postmenopausal osteoporosis patients with deficiency of liver and kidney |
| JIANG Qian1 HUANG Jianhua2 ZHENG Jun3 LIU Yingjie1 |
1.TCM Pharmacy, Rui′an Hospital of Traditional Chinese Medicine, Zhejiang Province, Rui′an 325200, China;
2.Department of Traditional Chinese Medicine and Traumatology, Rui′an People′s Hospital, Zhejiang Province, Rui′an 325200, China;
3.Department of Radiology, Rui′an People′s Hospital, Zhejiang Province, Rui′an 325200, China |
|
|
|
Abstract Objective To investigate the effect of Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets on bone mineral density, estradiol and immune function in postmenopausal osteoporosis (PMO) patients with deficiency of liver and kidney. Methods Two hundred PMO patients with deficiency of liver and kidney in Rui′an Hospital of Traditional Chinese Medicine from October 2014 to April 2016 were selected, and they were divided into control group and treatment group by random number table, with 100 cases in each group. The control group was given Alendronate Sodium and Vitamin D3 Tablets combined with Gukang Capsules, while the treatment group was treated with Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets. The bone mineral density, estradiol and immune function were compared between the two groups. Results Compared with before treatment, the bone mineral density of lumbar 1- lumbar 4 (L1-L4) and femoral neck (FN), serum estradiol, IgG and IgM in two groups increased (P ＜ 0.05). After treatment, the bone mineral density of L1-L4 and FN, serum estradiol, IgG and IgM in treatment group were higher than those in control group (P ＜ 0.05). There was no statistically significant difference in the IgA level between the two groups (P ＞ 0.05). Conclusion Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets in treatment of PMO patients with deficiency of liver and kidney can effectively improve immune function, regulate hormone levels and increase bone mineral density.
|
|
|
| Fund:浙江省瑞安市科技创新项目计划（MS2015043）。 |
|
|
|
| Cite this article: |
|
JIANG Qian1 HUANG Jianhua2 ZHENG Jun3 LIU Yingjie1. Effect of Modified Zhibai Dihuang Pills combined with Alendronate Sodium and Vitamin D3 Tablets on bone mineral density, estradiol and immune function in postmenopausal osteoporosis patients with deficiency of liver and kidney[J]. 中国医药导报, 2018, 15(23): 117-120.
|
|
|
|
| URL: |
| http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I23/117 |
[1] 崔宝甲，张乌云，曲志国.绝经后女性骨代谢生化指标与骨质疏松性腰椎骨折之间的相关性[J].中国骨质疏松杂志，2017，23（7）：900-903.
[2] Wei YK，Ma HL，Guo YZ，et al. Association of the IGF-1 rs35767 and rs972936 polymorphisms with the risk of osteoporosis in a Chinese postmenopausal female population [J]. Genet Mol Res，2015，14（4）：14325-14330.
[3] 孙艳红，韩正云，李建民.补肾健骨汤对绝经后骨质疏松症患者骨密度及骨代谢指标的影响[J].河北中医药学报，2017，32（1）：14-16.
[4] 沈霖，杨艳萍，谢晶.国人原发性骨质疏松症诊断标准研究[J].中国骨医骨伤科杂志，2003，11（2）：1-4.
[5] 郑筱萸.中药新药临床研究指导原则（试行）[S].北京：中国医药杂志科技出版社，2002：356-360.
[6] Luo J，Hendryx M，Safford MM，et al. Newly Developed Chronic Conditions and Changes in Health-Related Quality of Life in Postmenopausal Women [J]. J Am Geriatr Soc，2015，63（11）：2349-2357.
[7] Komm BS，Morgenstern D，A Yamamoto L，et al. The safety and tolerability profile of therapies for the prevention and treatment of osteoporosis in postmenopausal women [J]. Expert Rev Clin Pharmacol，2015，8（6）：769-784.
[8] 王晓燕，常时新，李冠武，等.青娥丸对去卵巢大鼠骨质疏松骨微循环的作用机制研究[J].环球中医药，2017，10（7）：702-707.
[9] 李建军，蔡榕琪，孟依临，等.特定冬季服用补肾中药对绝经后骨质疏松症患者骨吸收影响的研究[J].世界中医药，2017，12（9）：2109-2113.
[10] 付江涛，彭页，黄永红，等.补肝益肾方治疗绝经后骨质疏松症的临床观察[J].中国医药导报，2017，14（33）：86-89，93.
[11] Salvatori R. Letter to the Editor：Comment on "Effect of Growth Hormone Treatment on Fractures and Quality of Life in Postmenopausal Osteoporosis：A 10-Year Follow-Up Study" by Kratz E.，et al. [J]. J Clin Endocrinol Metab，2015，100（11）：L107.
[12] 王永军，赵斌，刘宗仁，等.滋肾调肝法治疗绝经后骨质疏松症的疗效观察[J].中国现代医生，2017，55（19）：115-118，134.
[13] 祁珊珊.去卵巢对骨质疏松大鼠皮肤衰老的影响[J].中国实验动物学报，2017，25（3）：325-328.
[14] 秦臻，任艳玲.从“精不足者补之以味”探讨绝经后骨质疏松症的防治[J].中医杂志，2017，58（12）：1021-1023.
[15] 魏文智，王秋莲.利塞膦酸钠结合碳酸钙D3片治疗对绝经后骨质疏松症患者疼痛和骨密度的影响[J].中国医药，2017，12（8）：1239-1242.
[16] Shi XL，Li CW，Liang BC，et al. Weak cation magnetic separation technology and MALDI-TOF-MS in screening serum protein markers in primary type I osteoporosis [J]. Genet Mol Res，2015，15（4）：15285-15294.
[17] 王欣怡，张本生，刘晓蓉，等.阿仑膦酸钠对绝经后骨质疏松症老年女性血清总碱性磷酸酶、骨特异性碱性磷酸酶的影响[J].中国药师，2017，20（7）：1260-1261，1298.
[18] Stagraczyński M，Kulczyk T，Leszczyński P，et al. Number of teeth and hormonal profile of postmenopausal women with osteoporosis，osteopenia and normal bone mineral density--a preliminary study [J]. Pol Merkur Lekarski，2015，39（232）：214-218.
[19] 高静，毛春英，章建霞，等.阿仑膦酸钠联合营养运动干预用于绝经后骨质疏松症的疗效[J].中国生化药物杂志，2017，37（1）：163-164，168.
[20] Silva TR，Franz R，Maturana MA，et al. Associations between body composition and lifestyle factors with bone mineral density according to time since menopause in women from Southern Brazil：a cross-sectional study [J]. BMC Endocr Disord，2015，15（1）：71.
[21] 吴晨，姜凤依，李欣，等.独活寄生汤联合钙尔奇对绝经后骨质疏松症患者骨代谢标志物的影响[J].中医药信息，2017，34（1）：77-80.
[22] 任一，陆耀宇，黄月娜，等.鹿角壮骨胶囊对绝经后骨质疏松症患者生殖内分泌激素及骨代谢的影响[J].中国药房，2017，28（2）：212-215.
[23] 王丽丽，房经武，王金国.补肾生骨颗粒对肾虚血瘀型绝经后骨质疏松症BMD、E2、BALP、N-MID的影响[J].世界中医药，2017，12（2）：293-298.
[24] 张长彪，彭冉东，赵军，等.益肾地黄汤联合利塞膦酸钠治疗肾阳虚型绝经后骨质疏松症45例[J].西部中医药，2017，30（4）：1-4.
[25] 任一，陆耀宇，黄月娜，等.鹿角壮骨胶囊对绝经后骨质疏松症患者生殖内分泌激素及骨代谢的影响[J].中国药房，2017，28（2）：212-215.
[26] 卢朝霞，王欣，周少怀.补肾健脾汤对绝经后骨质疏松症患者细胞因子及骨密度水平的影响[J].陕西中医，2017，38（4）：438-439. |
|
|
|
