未成熟粒细胞计数早期预测重度急性胰腺炎的应用价值

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Abstract Objective To evaluate the early predictive value of immature granulocyte count and combined detection of severe acute pancreatitis (SAP). Methods The clinical data of 63 patients with acute pancreatitis who were admitted to Hangzhou First People′s Hospital from February to December 2017 was analyzed retrospectively, and the patients were divided into severe group (22 cases) and mild - to - moderate group (41 cases) according to whether the patient had persistent organ failure or local complications. At the time of admission, patients were checked about immature granulocyte count (IG#), immature granulocyte percent (IG%), C-reactive protein (CRP), procalcitonin (PCT), blood routine and biochemical routine. In the univariate analysis, parameters with statistical differences between the groups were included in the multivariate analysis. Finally, ROC curve was used to compare the predictive value of IG%, PCT, CRP and combined detection in the early determination of severe acute pancreatitis. Results The intra-abdominal pressure (IAP), acute physiology and chronic health evaluation (APACHE Ⅱ) scores, CT severity index (CTSI) scores and modified Marshall scores of the severe group were significantly higher than those of the mild - to - moderate group (P ＜ 0.001). In laboratory indicators, there were significant differences in CRP, PCT, IG% and albumin between the two groups (P < 0.001); multivariate analysis showed that IG% (P = 0.026), CRP (P = 0.011), and PCT (P = 0.029) were independent risk factors to predict severe acute pancreatitis. The ROC curve showed that CRP, PCT, and IG% all proved to have predictive value for severe acute pancreatitis (P ＜ 0.001). The combined detection of IG%+CRP+PCT had a higher AUC than the single indicator (P ＜ 0.001). Conclusion Within 48 hours of the attack of acute pancreatitis, IG% is a useful index for predicting SAP. IG%, CRP, and PCT are independent risk factors to predict SAP, and the combination of the three indicators has a higher sensitivity and specificity in the assessment of severity evaluation.

Key words： Severe acute pancreatitis Immature granulocyte C-reactive protein Procalcitonin

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	WAN Yafeng1 WANG Li2

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WAN Yafeng1 WANG Li2. Application value of immature granulocyte count in the early prediction of severe acute pancreatitis[J]. 中国医药导报, 2018, 15(23): 104-108.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I23/104

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