原发性高血压患者血清FKN水平与血管内皮功能的关系

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Abstract Objective To explore the changes of serum fractalkine (FKN) level in patients with essential hypertension (EH) and its effect on vascular endothelial function. Methods One hundred and six EH patients in Sanya People's Hospital from July 2016 to July 2017 were selected as the observation group, 80 cases of healthy check-up were selected as the control group. The levels of serum FKN and high sensitive C reactive protein (hs-CRP), endothelin (ET-1) and nitric oxide (NO), two methyl arginine (ADMA) and brachial artery endothelial dependent vasodilation (FMD) of observation group at admission and control group were compared; the changes of blood pressure of observation group before and after treatment were observed; the serum levels of FKN, hs-CRP, ET-1, NO, ADMA and FMD in the observation group before and after treatment were compared; the correlation between serum FKN and hs-CRP, ET-1, NO, ADMA and FMD in EH patients was analyzed. Results At admission, the levels of serum FKN, hs-CRP, ET-1 and ADMA in the observation group were significantly higher than those in the control group (P ＜ 0.05), while the levels of serum NO and FMD in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, the systolic and diastolic pressures of the observation group were significantly lower than those before treatment, there was a statistically significant difference (P ＜ 0.05). The levels of serum FKN, hs-CRP, ET-1 and ADMA in the observation group were significantly lower than those before treatment, and the levels of NO and FMD were significantly higher than those before treatment (P ＜ 0.05). Pearson correlation analysis showed that serum FKN level was positively correlated with hs-CRP, ET-1 and ADMA level in EH patients (r = 0.332, 0.456, 0.432, all P ＜ 0.05), and negatively correlated with NO and FMD (r = -0.443, -0.505, all P ＜ 0.05). Conclusion The serum level of FKN in EH patients is abnormal elevate and affects the endothelial function of blood vessels. Elevated FKN level may be associated with increased blood pressure mediated vascular injury.

Key words： Essential hypertension Fractalkine Endothelial function Correlation

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	CHEN Qijing LUO Jiangbin ZHANG Yunbo CHEN Lin

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CHEN Qijing LUO Jiangbin ZHANG Yunbo CHEN Lin. The relationship between serum FKN level and vascular endothelial function in patients with essential hypertension[J]. 中国医药导报, 2018, 15(23): 45-48.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I23/45

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