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The clinical value of ultrasound, digital mammography and MRI in diagnosis benign and malignant breast diseases |
LAI Wei1 XIAN Yunkai2 CHEN Fang3 LIU Lizhen1 LI Denghui1 JIANG Shuanglan2 LIU Jianxin1 GUO Qinglu4▲ |
1.Department of Radiology, Dongguan Eighth People′s Hospital, Dongguan 523325, China;
2.Department of Ultrasound, Dongguan Eighth People′s Hospital, Guangdong 523325, China;
3.Department of Radiology, Affiliated Mindong Hospital of Fujian Medical University, Ningde 352000, China;
4.Department of Radiology, Guangdong Women and Children Hospital, Guangzhou 510010, China |
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Abstract Objective To investigate the clinical diagnostic value of ultrasound, digital mammography (DM), MRI and combined diagnosis of benign and malignant breast lesions. Methods The breast ultrasound, DM, MRI features and clinical data of 56 lesions in 53 patients in Dongguan Eighth People′s Hospital and Affiliated Mindong Hospital of Fujian Medical University were retrospectively analyzed form April 2015 to March 2018. Based on the BI-RADS, benign and malignant lesions were classified and compared with pathology. The ROCs were plotted and the area under the curve (AUC) were calculated, and the diagnostic efficacy of each and combined examinations were analyzed. Results There were 56 lesions in 53 patients, 38 located in benign and 18 located in malignant. In the 38 benign lesions group, according to the ultrasound dignosis, there were 3 cases of type Ⅱ, 23 cases of type Ⅲ, 9 cases of type Ⅳa and 3 cases of type Ⅳb; according to the DM dignosis, there were 5 cases of type 0, 8 cases of type Ⅱ, 12 cases of type Ⅲ, 7 cases of type Ⅳa and 4 cases of type Ⅳb; according to the MRI dignosis, there were 7 cases of type Ⅱ, 17 cases of type Ⅲ, 11 cases of type Ⅳa, 2 cases of type Ⅳb, and 1 case of type Ⅳc. In the 18 malignant lesions group, according to the ultrasound dignosis, there were 2 cases of type 0, 1 case of type Ⅲ, 6 cases of type Ⅳa, 4 cases of type Ⅳb, 4 cases of type Ⅳc and 1 case of type Ⅴ; according to the DM dignosis, there were 2 cases of type 0, 2 cases of type Ⅲ, 3 cases of type Ⅳa, 2 cases of type Ⅳb, 2 cases of type Ⅳc and 7 cases of type Ⅴ; according to the MRI dignosis, there were 1 case of type Ⅳa, 4 cases of type Ⅳb and 13 cases of type Ⅴ. The AUC of combination of three techniques and MRI, DM, ultrasound were 0.987, 0.976, 0.809, 0.779 respectively, the three combined examination and MRI diagnostic efficacy superior to ultrasound and DM (P < 0.05), and the combined examination and MRI no significant difference(P = 0.308). Conclusion There have some ultrasound, DM and MRI had features in benign and malignant breast disease, a variety of imaging methods of comprehensive utilization can improve the diagnostic performance.
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[1] Chen W,Zheng R,Zhang S,et al. Cancer incidence and mortality in China in 2013:an analysis based on urbanization level [J]. Chin J Cancer Res,2017,29(1):1-10.
[2] 季文祥,胡剑峰,夏建国,等.磁共振弥散加权成像、动态增强技术联合鉴别乳腺良恶性病变[J].分子影像学杂志,2017,40(4):405-408.
[3] D'Orsi,Carl J. ACR BI-RADS atlas:breast imaging reporting and data system [M]. American College of Radiology,2013.
[4] Adler DD,Carson PL,Rubin JM,et al. Doppler ultrasound color flow imaging in the study of breast cancer:preliminary findings[J]. Ultrasound Med Biol,1990,16(6):553-559.
[5] Buadu LD,Murakami J,Murayama S,et al. Breast lesions:correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis[J]. Radiology,1996,200(3):639-649.
[6] 夏晓天,何萍青,林燕苹,等.乳腺X线摄影、超声与MRI增强检查在乳腺疾病诊断中的比较[J].外科理论与实践,2010,15(5):473-476.
[7] Krekel NMA,Zonderhuis BM,Schreurs HWH,et al. Ultrasound-guided breast-sparing surgery to improve cosmetic outcomes and quality of life. A prospective multicentre randomised controlled clinical trial comparing ultrasound-guided surgery to traditional palpation-guided surgery (COBALT trial)[J]. BMC Surg,2011,11(1):8.
[8] Senkus E,Kyriakides S,Ohno S,et al. Primary breast cancer:ESMO Clinical Practice Guidelines for diagnosis,treatment and follow-up [J]. Annals Oncol,2015,26(suppl_5):v8-v30.
[9] 李继光,孙业全,张丰明,等.声弹性成像、常规超声、钼靶X线技术在乳腺癌诊断中的应用[J].中华医学超声杂志:电子版,2014,11(10):845-850.
[10] 吴朝贵,底炜.彩色多普勒超声及弹性成像诊断乳腺癌的应用价值[J].中国超声医学杂志,2015,31(9):844-846.
[11] 赵青,牟洋,赵献萍,等.超声弹性成像与钼靶对乳腺肿块BI-RADS分类诊断价值[J].中华实用诊断与治疗杂志,2017,31(6):589-591.
[12] 中国抗癌协会乳腺癌专业委员会.中国抗癌协会乳腺癌诊治指南与规范(2017年版)[J].中国癌症杂志,2017, 27(9):695-759.
[13] 邵琳,葛宇曦,陆黎,等.乳腺X线检查BI-RADS4级中乳腺浸润性导管癌和纤维腺瘤的鉴别诊断[J].实用放射学杂志,2016,32(9):1371-1373,1397.
[14] Nyante SJ,Lee SS,Benefield TS,et al. The association between mammographic calcifications and breast cancer prognostic factors in a population‐based registry cohort [J]. Cancer,2017,123(2):219-227.
[15] 杜岚,杨敬春,常莹.标准乳腺MRI与腋窝超声鉴别乳腺癌有无转移及晚期腋窝淋巴结病变的差异[J].中国医药导报,2017,14(35):168-171.
[16] Spick C,Bickel H,Pinker K,et al. Diffusion‐weighted MRI of breast lesions:a prospective clinical investigation of the quantitative imaging biomarker characteristics of reproducibility,repeatability,and diagnostic accuracy[J]. NMR in Biomedicine,2016,29(10):1445-1453.
[17] Dietzel M,Baltzer PAT,Vag T,et al. The adjacent vessel sign on breast MRI:new data and a subgroup analysis for 1,084 histologically verified cases [J]. Korean J Radiol,2010,11(2):178-186.
[18] 张亚平,董光,耿海,等.DCE-MRI和DWI对乳腺腺病和乳腺癌的诊断价值[J].实用放射学杂志,2017,(4):533-536,553.
[19] Kul S,Cansu A,Alhan E,et al. Contribution of diffusion-weighted imaging to dynamic contrast-enhanced MRI in the characterization of breast tumors[J]. AJR Am J Roentgenol,2011,196(1):210-217.
[20] Greenwood HI,Heller SL,Kim S,et al. Ductal carcinoma in situ of the breasts:review of MR imaging features [J]. Radiographics,2013,33(6):1569-1588.
[21] 褚巍,杨沪,宋燕,等.高频彩色多普勒超声早期诊断乳腺癌腋窝淋巴结转移的临床应用价值[J].癌症进展,2018,16(3):309-311,338.
[22] 姚瑶,李新华.超声联合弹性成像在非哺乳期乳腺癌诊断中的应用价值分析[J].癌症进展,2016,14(7):667-670. |
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