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| The value of color Doppler ultrasonography in the evaluation of diabetic lower extremity vascular disease and its relationship with serum Lp-PLA2，25 （OH） D3 levels |
| CHENG Qi1 TAN Yongpan2 SONG Quan1 HE Yufang3 |
1.Department of Function, the First Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050010, China;
2.Department of Ultrasound, the Fourth Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050010, China;
3.Department of Ultrasound, the First Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050010, China |
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Abstract Objective To study the value of color Doppler ultrasonography in the evaluation of diabetic lower extremity vascular disease and its relationship with serum lipoprotein related phospholipase A2 (Lp-PLA2) and 25-hydroxyvitamin D3 [25(OH)D3] levels. Methods From February 2015 to February 2016, 200 patients with diabetes in the First Hospital of Shijiazhuang were divided into group A with 43 cases of diabetic lower extremity vascular disease, group B with 157 cases of no diabetic lower extremity vascular disease according to color Doppler ultrasonography examination results. And 40 cases of healthy check-up were selected as healthy control group. The arterial diameter and arterial blood flow in each group was examined by color Doppler ultrasonography, and serum Lp-PLA2, 25(OH)D3 levels were detected by enzyme-linked immunosorbent assay, Pearson correlation analysis was used to analyze the association between artery diameter and blood flow, serum Lp-PLA2, 25 (OH)D3. Results The femoral artery, popliteal artery, dorsalis pedis artery diameter of group A were significantly lower than those of group B and healthy control group, and femoral artery, popliteal artery, dorsalis pedis artery blood flow were significantly lower than those of group B and healthy control group (P < 0.05), the above indexes were not statistically different between the healthy control group and the group B (P > 0.05). The level of serum Lp-PLA2 in group A was significantly higher than that of group B and control group, 25 (OH)D3 level was significantly lower than group B and healthy control group (P < 0.05), while there was no significant difference in levels of Lp-PLA2 and 25 (OH)D3 between the healthy control group and group B (P > 0.05). The vascular diameter and blood flow of patients with lower extremity arterial disease related to diabetic were positively correlated with the level of serum Lp-PLA2 (r = 0.562, 0.621, P ＜ 0.05）, and was negatively correlated with the level of 25 (OH)D3 (r = -0.663, -0.582, P ＜ 0.05). Conclusion Patients with diabetic lower extremity vascular disease show the presence of lower extremity arterial stenosis, slow flow of blood, and abnormal changes in serum Lp-PLA2 and 25 (OH)D3 levels. The intra arterial diameter and arterial blood flow are closely related to the levels of serum Lp-PLA2 and 25 (OH)D3.
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