枸橼酸芬太尼联合帕瑞昔布钠在椎间孔镜手术中的镇痛、镇静效果

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Abstract Objective To probe into the influence of Fentanyl Citrate combined with Parecoxib Sodium anesthesia for percutaneous transforaminal endoscopic discectomy (PTED) in patients with restlessness, pain and sedative effects. Methods A total of 78 patients treated with percutaneous transforaminal endoscopic surgery in Department of Pain of Dongguan Fifth People′s Hospital from January to December in 2016 were selected as study objects, and they were divided into two groups by random method, 39 patients of the control group were taken Fentanyl Citrate 50 μg diluted with normal saline to 5 mL in preoperative intravenous infusion of about 20 min, while 39 patients of the observation group were taken preoperative intramuscular injection of Parecoxib Sodium 40 mg, and were taken the Fentanyl Citrate (50 g) diluted to 5 mL spinal injection anesthesia when the puncture needle reaches the fiber ring during the operation, and the changes of blood pressure and heart rate (HR) index of patients of two groups were recorded before anesthesia (T0), guided needle puncture (T1), annulus fibrosus fenestration (T2), nucleus pulposus removal (T3) and radiofrequency ablation (T4). And the degree of pain and the state of sedation during each period during the operation of patients in the two groups were evaluated by the Ramsay sedation rating scale and visual analogue scale (VAS). Results There was no significant difference in the blood pressure and HR before anesthesia between the two groups (P > 0.05). At T1-T4, the blood pressure and HR in the observation group were fluctuated with more than T0, but closed to the normal value, the blood pressure and HR in the control group significantly increased, and the difference between the two groups was statistically significant (P < 0.05). In each period except T0, VAS of patients in the observation group was lower, and Ramsay was higher than that of the control group, and the differences were statistically significant (P < 0.05). Conclusion The Fentanyl Citrate combined with Parecoxib Sodium anesthesia in application of percutaneous transforaminal endoscopic discectomy which can reduce the blood pressure and HR and other indicators, and the postoperative analgesia and sedation effect are significant, thus it is worth promoting and using.

Key words： Ventani Cyclooxygenase inhibitor Conscious sedation Analgesia Intervertebral foramen

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	LIU Bo YE Yongjun WANG Zebo ZHANG Zhihai XIE Xia

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LIU Bo YE Yongjun WANG Zebo ZHANG Zhihai XIE Xia. Analgesic and sedative effects of Fentanyl Citrate combined with Parecoxib Sodium anesthesia in procedure of intervertebral foraminoscopy[J]. 中国医药导报, 2018, 15(22): 99-102.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I22/99

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