唾液幽门螺杆菌检测在胃癌发生发展中的价值

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Abstract Objective To investigate the correlation between salivary Helicobacter pylori (Hp) and various stages of gastric cancer development. Methods Saliva was collected from 201 patients with pathologically diagnosed superficial gastritis, atrophic gastritis, dysplasia, and gastric cancer in Beijing Luhe Hospital, Capital Medical University from January 2016 to October 2017. The HPS test was used to detect Hp in saliva. The incidence and correlation of Hp infection were analyzed according to age, sex, periodontal status, and different gastric lesions. Results Among all patients included in the trial, the male infection rate (75.5%) was higher than that of female (54.5%) (P < 0.05). The Hp infection rates of middle-aged and elderly patients were 69.9% and 75.4% respectively, which were significantly different from the younger ones (42.9%) (P < 0.05). The positive rates of oral Hp in the atrophic gastritis group, atypical hyperplasia group, and gastric cancer group were 64.5%, 76.0%, and 75.0%, respectively, which were significantly higher than superficial gastritis group (44.4%), and the differences were statistically significant (P < 0.05). The infection rates of gingivitis group and periodontitis group were higher than periodontal health group, and the differences were statistically significant (P < 0.05). Conclusion Oral Hp infection rate is higher in the oral cavity, and related to age, gender and periodontal disease. The oral Hp infection rate is related to the precancerous lesions and gastric cancer. The presence of oral Hp may be an important risk factor for gastric precancerous lesions and gastric cancer.

Key words： Helicobacter pylori Saliva Gastric precancerous lesions Gastric cancer Periodontitis

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	LUO Wei1 ZHU Zhichao1 XU Baohong1▲ LUO Zhenhua2

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LUO Wei1 ZHU Zhichao1 XU Baohong1▲ LUO Zhenhua2. The value of the Helicobacter pylori in saliva in the occurrence and development of gastric cancer[J]. 中国医药导报, 2018, 15(22): 88-91.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I22/88

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