丙氨酰-谷氨酰胺对重症脑出血患者的营养治疗作用及对免疫功能的影响

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Abstract Objective To investigate the effects of propylene ammonia acyl-glutamine on nutrition and immune function in patients with severe cerebral hemorrhage. Methods Sixty-eight patients of severe cerebral hemorrhage admitted to Maanshan Shiqiye Hospital from May 2015 to June 2016 were randomly divided into routine group (32 cases) and AlaGln group (36 cases). The routine group received conventional treatment, while the AlaGln group received extra 10 g of AlaGln in 400 mL of compound amino acids, ivgtt, qd, for two weeks. Bowel function, the immune indices of liver function and renal function, infections score before and after treatment between the two groups were compared. Results The improvement of intestinal function score in AlaGln group was significantly better than that in the routine group, and the difference was statistically significant (P < 0.05). The levels of serum albumin, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) of patients in the two groups before treatment were compared, there was no statistically significant difference (P > 0.05). The levels of serum albumin and IgG at day 7, IgG, IgA and IgM at day 14 in AlaGln group were compared with those in the routine group at day 7, and the differences were statistically significant (P < 0.05). After two weeks of treatment, the incidence of hospital infection in AlaGln group was significantly lower than that in the routine group, and the difference was statistically significant (P < 0.05). There was no statistically significant difference in liver and kidney function between the two groups before treatment and at day 7 and 14 after treatment (P > 0.05). Conclusion For patients with severe cerebral hemorrhage, propylene ammonia acyl-glutamine supplements can improve bowel function and nutrition; protect the intestinal mucosal barrier and immune function while reduce the nosocomial infection rate and maintain normal liver and renal function.

Key words： Propylene ammonia acyl-glutamine Severe cerebral hemorrhage Bowel function score Nutritional therapy Immune function Nosocomial infection

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	ZHOU Yidong1 DONG Xuemei1 ZHANG Dingfeng1 SHEN Jiwei1 PENG Wangsong1 XIE Yuan2 LU Weihua3

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ZHOU Yidong1 DONG Xuemei1 ZHANG Dingfeng1 SHEN Jiwei1 PENG Wangsong1 XIE Yuan2 LU Weihua3. Effects of propylene ammonia acyl-glutamine on nutrition and immune function in patients with severe cerebral hemorrhage[J]. 中国医药导报, 2018, 15(22): 77-80.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I22/77

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