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| Value of procalcitonin, high-sensitivity C-reactive protein and D-dimer in diagnosis and prognosis of acute respiratory distress syndrome caused by sepsis |
| XIAN Li′na YANG Yuanzheng CHEN Wei SUN Guangxiao |
| Intensive Care Unit, the First Hospital Affiliated to Hainan Medical College, Hainan Province, Haikou 570102, China |
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Abstract Objective To investigate the value of diagnosis and prognostic evaluation on acute respiratory distress syndrome (ARDS) caused by sepsis and procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), D-dimer. Methods From January 2015 to January 2017, in the First Hospital Affiliated to Hainan Medical College, 82 sepsis-causing ARDS patients were selected. According to the severity of patients, they were divided into severe group (33 cases) and non-severe group (49 cases), according to the ending of patients, they were divided into non-death group (69 cases) and death group (13 cases). At the same period, 100 healthy physical examinations were selected as healthy control group. Serum PCT, hs-CRP, and D-dimer levels in the group were evaluated and compared. Results Serum PCT, hs-CRP, and D-dimer levels in Severe group > non-severe group > healthy control group, the differences were statistically significant (P < 0.05); serum PCT, hs-CRP and D-dimer levels in death group > non-death group > healthy control group, the differences were statistically significant (P < 0.05). Correlation analysis revealed that serum PCT, hs-CRP and D-dimer levels were positively correlated with patient outcome (r = 0.634, 0.518, 0.537, P < 0.05). Conclusion Serum PCT, hs-CRP, and D-dimer levels are associated with sepsis-induced ARDS disease and prognosis. The more severe the patient′s condition and the worse the prognosis, the higher the above-mentioned serum factor levels.
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