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| Efficacy and safety of calf spleen extract injection combined with S-1 in the treatment of advanced primary squamous cell carcinoma of the stomach |
| CHEN Long1 WANG Lin4 HE Donglei2 LIANG Dong1 LIN Haifeng3 FENG Jun1 HUANG Ping4 |
1.Department of Oncology, the Third People′s Hospital of Hainan Province Nongken Sanya Hospital, Hainan Province, Sanya 572000, China;
2.Department of Gastrointestinal Cancer Surgery, the First Affiliated Hospital of Hainan Medical College, Hainan Province, Haikou 570100, China;
3.Department of Oncology, the Second Affiliated Hospital of Hainan Medical College, Hainan Province, Haikou 570100, China;
4.Department of Gastrointestinal Cancer Surgery, Hainan General Hospital, Hainan Province, Haikou 570100, China |
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Abstract Objective To compare the efficacy and safety of calf spleen extract injection combined with S-1 in the treatment of advanced primary squamous cell carcinoma of the stomach. Methods A total of 31 advanced primary squamous cell carcinoma of the stomach patients with Karnofsky Performance Status (KPS) score≥60 scores and expected survival time≥3 months were enrolled from September 2011 to January 2017 in the Third People′s Hospital of Hainan Province and Hainan General Hospital. They were divided into the study group and the control group by random number table method, with 16 cases in the study group and 15 cases in the control group respectively. The patients in the study group received calf spleen extract injection combined with oral S-1 treatment. The control group received oral S-1 treatment. Each group was treated for three weeks. The efficacy and adverse events in the two groups were observed and compared post treatment for 3 months. Results The effective rates in the study group and the control group were 50.0% and 33.3% respectively, the disease control rates were 87.5% and 66.7% respectively, and the effective rate and disease control rate in the study group were both higher than those in the control group the differences were statistically significant(P ＜ 0.05). The median survival was 10.0 months in the study group and 7.0 months in the control group, the differences were statistically significant (P ＜ 0.05). The most common adverse events in the two groups were myelosuppression, diarrhea, nausea and vomiting, oral mucositis, allergy, renal impairment and so on, the incidence of adverse reactions in the two groups had no significant difference (P ＞ 0.05). Conclusion Efficacy and safety of calf spleen extract injection combined with S-1 in the treatment of advanced primary squamous cell carcinoma of the stomach are better than S-1， with less adverse reactions and it is worth clinical promotion.
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