季节变化对体外受精-胚胎移植妊娠结局的影响

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Abstract Objective To investigate the influences of seasonal variability on in vitro fertilization (IVF) and embryo transfer (ET). Methods The data of 4505 IVF cycles in 6 years (from January 2010 to December 2016) treated for tube factor, oligospermatism and/or asthenospermia in Reproductive Medical Center, the International Peace Maternity and Child Health Hospital were collected retrospectively. According to the day of ET, these cycles were divided into four season groups (1172 cycles in Spring, 1356 in Summer, 1115 in Autumn, and 861 in Winter). All cycles were administered with the GnRH analog formula. Response of ovarian, embryo quality, and reproductive outcomes were compared among groups. Results The total dose and duration of gonadotropin were similar in each group (P > 0.05). The matured oocytes and fertilization number, fertilization rates, cleavage and valid embryo numbers were significantly higher in Autumn (P < 0.05), whereas the valid embryos were fewer in Winter (P < 0.05). Total oocyte numbers and maturation rates in each season group were comparable (P > 0.05). The implantation rate, clinical pregnancy rate, live birth rate and miscarriage rate among four seasons had no significant differences (P > 0.05). Conclusion Seasonality may have influences on fertilization and embryo development, which are insufficient to change the pregnancy outcomes of IVF-ET treatment. It is feasible that IVF-ET treatment could be provided in any season.

Key words： Season In vitro fertilization Weather Ovarian stimulation Pregnancy rate

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	XIAO Yu WANG Min WANG Yong

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XIAO Yu WANG Min WANG Yong. Influences of seasonal variability on pregnancy outcomes of in vitro fertilization and embryo transfer[J]. 中国医药导报, 2018, 15(20): 120-123.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I20/120

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