|
|
|
| Effect of Danhong Injection combined with closed thoracic drainage plus four anti-tuberculous drugs in treating tuberculous pleural effusion |
| QIAO Ruijun |
| The First Ward of Tuberculosis, the Tenth People′s Hospital of Shenyang, Liaoning Province, Shenyang 110044, China |
|
|
|
Abstract Objective To explore the effect of Danhong Injection combined with closed thoracic drainage plus four anti-tuberculous drugs in treating tuberculous pleural effusion. Methods The 80 cases clinical data of early diagnose clearly tuberculous pleural effusion in the Tenth People′s Hospital of Shenyang from January to June in 2017 were selected and divided into control group (four anti-tuberculosis drugs, 40 cases) and combined treatment group (Danhong Injection cooperate thoracic close drainage and four anti-tuberculosis drugs, 40 cases) by different treatment method. The pleural effusion drainage time, pleural effusion drainage volume and hospital stays in the two groups were detected, the pleural thickness, lung function and the levels of IL-12, TNF-α, ADA in the two groups before and after treatment were compared and the clinical effects of two groups were detected. Results The pleural effusion drainage time, hospital stays in the combined treatment group were shorter than those of the control group (P < 0.05). After treatment, the pleural thickness and the levels of IL-12, TNF-α, ADA in the two groups were lower than those before treatment, and the levels of TLC, FVC, FEV1/FVC% were higher than before treatment, besides the pleural thickness and the levels of IL-12, TNF-α, ADA in the combined treatment group after treatment were lower than those in the control group, and the levels of TLC, FVC, FEV1/FVC% were higher than those of the control group, with statistically significant difference (P < 0.05). The clinical treatment total effective rate of combined treatment group was higher than that of the control group (P < 0.05). Conclusion Danhong Injection with closed thoracic drainage plus four anti-tuberculosis drugs in the treatment of tuberculous pleural effusion can shorten the time, increase the flow, and improve pleural thickness, lung function and pleural effusion, biochemical indicators and the clinical curative effect, which is worthy of clinical application.
|
|
|
|
|
|
[1] 郑春晓，甘艳.中心静脉导管胸腔闭式引流联合尿激酶胸腔内注射治疗结核性胸膜炎[J].河北医药，2016，38（5）：751-752.
[2] Fu X，Liu Y，Li L，et al. Human natural killer cells expressing the memory-associated marker CD45RO from tuberculous pleurisy respond more strongly and rapidly than CD45RO-natural killer cells following stimulation with interleukin-12 [J]. Immunology，2011，134（1）：41-49.
[3] 朱红艳.不同疗程左氧氟沙星联合四联抗结核疗法治疗结核性胸膜炎的临床疗效研究[J].实用心脑肺血管病杂志，2015，23（12）：96-98.
[4] Wang X，Yang Z，Fu Y，et al. Insight to the epidemiology and risk factors of extrapulmonary tuberculosis in Tianjin，China during 2006-2011 [J]. PloS One，2014，9（12）：e112 213.
[5] 中华医学会.临床诊疗指南结核病分册[M].北京：人民卫生出版社，2005.
[6] Hervé C，Bergot E，Veziris N，et al. Tuberculosis in 2015：from diagnosis to the detection of multiresistant cases [J]. Rev Des Malad Resp，2015，32（8）：784-790.
[7] 陈瑜，周玲霞.中西医结合治疗结核性包裹性胸腔积液的疗效观察[J].中国中医药科技，2015，22（5）：542-543.
[8] 张培元.肺结核诊断和治疗指南[J].中华结核和呼吸杂志，2001，24（2）：70-74.
[9] 王莉，常小红.不同疗程的左氧氟沙星与四联抗结核药合用对结核性胸膜炎的疗效[J].药物评价与研究，2016， 39（1）：108-111.
[10] Das DK. Age and sex distribution in malignant and tuberculous serous effusions：a study of 127 patients and review of the literature [J]. Geriatr Gerontol Int，2014，42（6）：334-342.
[11] 武凤华，温志华，朱先女，等.长疗程与短疗程使用左氧氟沙星治疗结核性胸膜炎的效果比较[J].广东医学，2014（16）：2616-2617.
[12] Mc Grath EE，Anderson PB. Diagnosis of pleural effusion：a systematic approach [J]. Am J Crit Care，2011，20（2）：119-128.
[13] 盖林林，管立学，李海波，等.结核感染T细胞斑点试验检测胸腔积液和外周血对结核性胸膜炎的诊断价值[J].中国医药导报，2016，13（22）：125-128.
[14] Vorster MJ，Allwood BW，Diacon AH，et al. Tuberculous pleural effusions：advances and controversies [J]. J Thoracic Dis，2015，7（6）：981.
[15] 许承斌，丁明霞，常媛媛，等.中心静脉导管胸腔闭式引流并尿激酶胸腔内注射治疗结核性胸膜炎的临床观察[J].临床医学，2014，34（3）：48-49.
[16] Takahashi K，Porcel JM，Lee P，et al. Year in review 2014：lung cancer，pleural diseases，respiratory infections and tuberculosis，bronchoscopic intervention and imaging [J]. Respirology，2015，20（4）：674-683.
[17] Peto HM，Pratt RH，Harrington TA，et al. Epidemiology of extrapulmonary tuberculosis in the United States，1993-2006 [J]. Clin Infect Dis，2009，49（9）：1350-1357.
[18] Cruz AT，Hwang KM，Birnbaum GD，et al. Adolescents with tuberculosis：a review of 145 cases [J]. Ped Inf Dis J，2013，32（9）：937-941.
[19] 彭德虎，胡锦兴，石琳，等.结核性胸膜炎患者血清与胸腔积液蛋白质组的初步分析[J].实用医学杂志，2010， 26（23）：4269-4271.
[20] 阳艳，游加宝.丹红注射液配合胸腔闭式引流加四联抗结核药物治疗结核性胸腔积液疗效观察[J].现代中西医结合杂志，2017，26（24）：2674-2676. |
|
|
|
