甲状腺功能异常患者出凝血功能指标变化的临床研究

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Abstract Objective To study the alteration and the value of platelet parameters and the blood clotting parameters in hypothyroidism patients. Methods Total of 120 patients with abnormal thyroid function were selected from January 2014 to September 2017 in Inpatient Department and Outpatient Clinic of Gansu Rehabilitation Center Hospital(“our hospital” for short). According to serum TSH, FT3, and FT4 levels, the patients were divided into the hyperthyroidism group consisted of 60 patients and hypothyroidism group consisted of 60 patients. In the same period, 60 healthy were selected as the control group. The levels of TSH, FT3, FT4 and platelet parameters (PLT, P-LCR, PDW) and prothrombin time (PT), activation partial thrombin time (APTT), fibrinogen (FIB) were observed in the three groups. Results There was no difference in PLT value among the three groups (P > 0.05). The contents of PDW, P-LCR and FIB in hyperthyroidism group were higher than those in the hypothyroidism group and the control group, the differences were statistically significant (P ＜ 0.05). APTT and PT levels of hyperthyroidism group were obviously lower than those in the hypothyroidism group and the control group, with statistically significant differences (P ＜ 0.05). Conclusion The coagulation function of patients with hyperthyroidism is in high coagulation state, which has a tendency of secondary thrombosis, and the coagulation function of patients with hypothyroidism is reduced and there is a risk of bleeding.

Key words： Thyroid function Coagulation function Abnormality

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	CHEN Tao SHI Xiu′e LIU Ling WANG Yanqiu JIN Ping▲ WANG Yiping

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CHEN Tao SHI Xiu′e LIU Ling WANG Yanqiu JIN Ping▲ WANG Yiping. Clinical study on the changes of coagulation function in patients with abnormal thyroid function[J]. 中国医药导报, 2018, 15(20): 105-107,111.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I20/105

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