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| Partial correlation analysis between osteoporosis and ectopic calcification |
| LIU Xueyuan1 YU Zhi2 XIONG Yibo1▲ DENG Zexi1 LU Shuihuan1 ZHAO Lei1 HE Jie1 TANG Huiming1 |
1.Department of Cadre Ward, the 181st Hospital of PLA, Guangxi Zhuang Autonomous Region, Guilin 541002, China;
2.Department of Ultrasonography, the 181st Hospital of PLA, Guangxi Zhuang Autonomous Region, Guilin 541002, China |
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Abstract Objective To investigate the relationship between osteoporosis and ectopic calcification in elderly inpatients. Methods Three hundred and twenty-two cases of elderly patients hospitalized in the 181st Hospital of PLA from March 2013 to September 2016 were selected. Gender, age and body mass index (BMI) were recorded. Bone mineral density (BMD) was measured in two sites of femur and lumbar spine. There were 88 patients of normal bone mass, 96 cases of osteopenia, 138 cases of osteoporosis. Bone mineral density of site L2-L4, bilateral femoral neck, trochanter and Wards triangle were measured by the DPX–NT dual-energy X-ray bone mineral density produced in America. Head, spine, knee joint, the lungs, bilateral carotid arteries, abdominal aorta, lower limb artery, liver, gallbladder, kidney were checked with CT, X-rays or color ultrasonic. BMD and calcification of the above organs were analyzed by partial correlation among the elderly, male and female groups. Results Compared in normal bone, osteopenia and osteoporosis groups: the differences of abdominal aortic calcification, lumbar compression fracture, knee joint degeneration or proliferation were statistically significant (P < 0.01). Compared with each other: the differences of abdominal aortic calcification, knee joint degeneration or proliferation were significantly severer in osteoporosis group than those in bone mass reduction group and bone normal group (P < 0.05); the lumbar compression fracture in bone mass reduction group or osteoporosis group was more common than that of normal group, the difference was statistically significant (P < 0.01). There was no difference in gallstone among all groups (P > 0.05). Partial correlation analysis according to ages: BMD was associated with lumbar fracture in all groups. BMD in all patients and elderly group were associated with abdominal aortic calcification, knee joint degeneration or hyperplasia and gallstone (P < 0.05). Calcification in carotid artery, abdominal aorta, lower extremity arterial, compared with the younger age group, the older age group were more obvious and the differences were statistically significant (P < 0.01); spinal degenerative changes and bone hyperplasia, knee joint degeneration, bone hyperplasia, urinary stone and gallstone were prevalent in older elderly group, the differences were statistically significant (P ＜ 0.05). Partial correlation analysis with gender: BMD was associated with abdominal aortic calcification, knee joint degeneration or hyperplasia and bile gallstone in male (P < 0.05). BMD was associated with kidney calcification, gallstone in female (P < 0.05). Conclusion BMD is associated with abdominal aortic calcification, lumbar compression fracture, renal calcification, knee joint degeneration, hyperplasia and gallstone.
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