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| Effect of Lienal Polypeptide Injection combined with mFOLFOX6 chemotherapy in treatment of advanced colon cancer and influence on immune function |
| MAO Shanshan CHENG Xiaozhen CUI Ronghua YUAN Jianghua WANG Meiqing |
| Department of Oncology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Hai′nan Province, Haikou 570208, China |
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Abstract Objective To investigate the clinical efficacy of Lienal Polypeptide Injection combined with mFOLFOX6 chemotherapy on advanced colon cancer chemotherapy and observe its effect on the immune function. Methods From January 2013 to December 2016, in Department of Oncology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, 80 advanced colon cancer patients were selected, according to random number table method, they were divided into observation group and control group, with 40 cases in each group. Patients of two groups were given mFOLFOX6 regimen for 4 cycles, and the observation group was given Lienal Polypeptide Injection combined with chemotherapy. After chemotherapy, the peripheral blood T lymphocyte subsets, the recent curative effect, the side effects of chemotherapy and KPS score in the two groups were compared. Results After chemotherapy, the number of CD3+,CD4+ T lymphocytes and the ratio of CD4+/CD8+ in the observation group increased, the differences were statistically significant (P < 0.05), the number of CD8+ T lymphocytes decreased, the difference was statistically significant (P < 0.05); after chemotherapy, the number of CD3+, CD4+ T lymphocytes and the ratio of CD4+/CD8+ in control group decreased, the differences were statistically significant (P < 0.05), the number of CD8+ T lymphocytes increased, the difference was statistically significant (P < 0.05); after chemotherapy, the number of CD3+, CD4+ T cells and the ratio of CD4+/CD8+ T cells in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05), the number of CD8+ T cells was lower, the difference was statistically significant (P < 0.05). The recent curative effect, total effective rate and disease control rate in the observation group were slightly higher than those in the control group, but the differences were not statistically significant (P > 0.05). The incidence rates of Ⅲ+Ⅳ degree anemia, leukopeniawere in the observation group after chemotherapy were lower than those in the control group, the differences were statistically significant (P < 0.05), and the incidence rates of peripheral sensory neuropathy, nausea and vomiting, thrombocytopenia, diarrhea, liver function damage and renal function damage in the two groups were compared, the differences were not statistically significant (P > 0.05). Compared with the control group, the KPS score and quality of life improvement of the observation group were higher after chemotherapy, the differences were statistically significant (P < 0.05). Conclusion Lienal Polypeptide Injection can effectively correct the disturbance of immune function in patients with advanced colon cancer during chemotherapy, alleviate the blood toxicity caused by chemotherapy and improve the quality of life of patients.
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