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| Relationship between expression of STAT5B and seizure occurrence in anaplastic gliomas |
| FENG Enshan1 LIANG Tingyu1 WANG Fang1 TANG Kai2 |
1.Department of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing 100000, China;
2.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China |
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Abstract Objective To identify the genes associated with the onset of seizure caused by anaplastic gliomas. Methods TCGA RNA-seq set from TCGA website was downloaded, there were 243 anaplastic glioma samples, the initial symptom of 119 cases was seizure and the initial symptom of 124 ones was not seizure. t test was performed to select differential genes between two groups. CGGA RNA-seq set was used for validation. The prognosis results were attained from Kaplan-Meier curves. Results In TCGA RNA-seq set, prognosis of patients with seizure was better than those without seizure(P = 0.04). 902 genes whose expression were discriminating between two groups. Through DAVID analysis of 902 genes, it showed that the pathway of regulation of multicellular organism growth including seven genes (STAT5B, AFG3L2, FTO, APP, GDF5, MBD5, PIK3CA) was different. simplify gene number, CGGA RNA-seq set was used for reducing gene number. Then STAT5B was left. But it could not affect prognosis of anaplastic gliomas. Conclusion In anaplastic gliomas, patients with seizure have better prognosis than those without seizure. The higher STAT5B expression, the lower frequency of seizure. The expression of STAT5B may be one of factors influencing seizure occurrence.
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