25-羟基维生素D与妊娠期糖尿病孕妇胰岛素抵抗的关系及意义

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Abstract Objective To investigate the relationship between 25-hydroxy vitamin D (25OHD) and insulin resistance in pregnant women with gestational diabetes mellitus (GDM) and its significance. Methods From April 2015 to August 2017, 98 cases of pregnant women diagnosed with GDM in General Hospital of Fushun Mining Bureau were selected as study group, 98 cases of normal pregnant women in the same period were selected as healthy control group. The serum levels of lipids, fasting blood glucose (FBG), fasting insulin (FINS), and 25OHD were detected, the insulin sensitivity adipokines retinol binding protein 4 (RBP4) and Visfatin level of pregnant women in two groups were measured, insulin resistance index (HOMA-IR) was counted, the relationship between 25OHD and HOMA-IR, RBP4, Visfatin were analyzed. Results Level of TG in the study group was significantly higher than that of the control group, the difference was not statistically significant (P < 0.05), while the levels of TC, HDL-C and LDL-C between two groups were not significantly different (P > 0.05); levels of FBG, FINS and HbA1c in the study group were significantly higher than those in the control group, the differences were statistically significant (P < 0.05); level of 25OHD in the study group was significantly lower than that in the control group, levels of HOMA-IR, RBP4 and Visfatin in the study group were significantly higher than those in the control group, the differences were statistically significant (P < 0.05). Correlation analysis showed that, 25OHD level was negatively correlated with levels of HOMA-IR, RBP4, Visfatin (r = -0.916, -0.526, -0.153, all P < 0.05). Conclusion Insulin resistance of pregnant women with GDM is closely related with serum 25OHD level, and therefore vitamin D supplementation for pregnant women may have a positive effect in alleviating insulin resistance, reducing related adipokines, and preventing gestational diabetes, it is worthy of further research.

Key words： Gestational diabetes mellitus 25-hydroxy vitamin D Insulin resistance Adipokines

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FU Dan. Relationship between 25-hydroxy vitamin D and insulin resistance in pregnant women with gestational diabetes mellitus and its significant[J]. 中国医药导报, 2018, 15(20): 79-82.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I20/79

[1] Ford ES，Ajani UA，McGuire LC，et al. Concentrations of serum vitamin D and the metabolic syndrome among US adults [J]. Diabetes Care，2005，28（5）：1228.
[2] Li YX，Zhou L. Vitamin D Deficiency，Obesity and Diabetes [J]. Cell Mol Biol（Noisy-le-grand），2015，61（3）：35-38.
[3] Xuan Y，Zhao HY，Liu JM. Vitamin D and type 2 diabetes mellitus （D2） [J]. J Diabetes，2013，5（3）：261-267.
[4] Angellotti E，Pittas AG. The Role of Vitamin D in the Prevention of Type 2 Diabetes：to D or Not to D? [J]. Endocrinology，2017，158（7）：2013-2021.
[5] Alzaim M，Wood RJ. Vitamin D and gestational diabetes mellitus[J].Nutr Rev，2013，71（3）：158-167.
[6] Pilz S，Kienreich K，Rutters F，et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes [J]. Curr Diab Rep，2013，13（2）：261-270.
[7] 钱荣立.第二届全国妊娠期糖尿病学术会议纪要[J].中国糖尿病杂志，2008，16 （5）：320.
[8] 孔晶，聂敏，邢小平.维生素D与妊娠糖尿病[J].基础医学与临床，2012，32（8）：870-874.
[9] Michael F. Vitamin D deficiency [J]. N Engl J Med，2007， 357（2）：266-281.
[10] 杨敏.妊娠期糖尿病患者血清25-羟维生素D水平及胰岛素抵抗的关系[J].中国妇幼保健，2013，28（5）：4639-4641.
[11] Urrutia RP，Thorp JM. Vitamin D in pregnancy： current concepts [J]. Curr Opin Obstet Gynecol，2012，13（24）：57-64.
[12] 杨立颖，张巍，范玲，等.北京城区健康育龄妇女血清25-羟维生素D水平及胰岛素抵抗的关系[J].中国妇产科临床杂志，2012，13（4）：263-266.
[13] Zhang Y，Gong Y，Xue H，et al. Vitamin D and gestational diabetes mellitus： a systematic review based on data free of Hawthorne effect [J]. BJOG，2017，38（2）：156-161.
[14] Valizadeh M，Piri Z，Mohammadian F，et al. The Impact of Vitamin D Supplementation on Post-Partum Glucose Tolerance and Insulin Resistance in Gestational Diabetes：A Randomized Controlled Trial [J]. Int J Endocrinol Metab，2016，14（2）：e34312.
[15] El Lithy A，Abdella RM，El-Faissal YM，et al. The relationship between low maternal serum vitamin D levels and glycemic control in gestational diabetes assessed by HbA1c levels：an observational cross-sectional study [J]. BMC Pregnancy Childbirth，2014，35（14）：362.
[16] Mutlu N，Esra H，Begum A，et al. Relation of maternal vitamin D status with gestational diabetes mellitus and perinatal outcome [J]. Afr Health Sci，2015，15（2）：523-531.
[17] Akbari M，Mosazadeh M，Lankarani KB，et al. The Effects of Vitamin D Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Gestational Diabetes：A Systematic Review and Meta-Analysis of Randomized Controlled Trials [J]. Horm Metab Res，2017，49（9）：647-653.
[18] Wood RJ. Vitamin D and adipegenesis：new molecular insight [J]. Nutr Rev，2008，66（1）：40-46.
[19] Yang Q，Grahaml TE，Mody N，et al. Serum retinol binding protein 4 contributes to insulin resistence in obesity and type 2 diabetes [J]. Nature，2005，436（7049）：356-362.
[20] 张黎明，高凌，帅红霞，等.维生素D对妊娠糖尿病胰岛素敏感性脂肪因子及肿瘤坏死因子-α的影响[J].医药导报，2014，33（5）：593-597.
[21] 邱彩玲，陈祥云，宣春，等.糖化血红蛋白、空腹血糖与D-二聚体联合检测在妊娠期糖尿病筛查中的临床应用[J].中国医学创新，2018，15（13）：49-52.
[22] 文芳梅，严建宇.老年2型糖尿病患者血清25-羟维生素D3水平与胰岛素抵抗的相关性[J].中国医药导报，2016，13（24）：77-80.