夫妻双方体重指数对体外受精结果影响

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Abstract Objective To explore the impact of the weight of both husband and wife on assisted reproductive outcomes. Methods A retrospective analysis of patients undergoing treatment at the Center for Reproduction and Genetics of the Affiliated Suzhou Hospital of Nanjing Medical University from August 2008 to October 2015 was conducted. A total of 1223 fresh in vitro fertilization(IVF) cycles were collected and grouped according to body mass index (BMI), they were divided into 3 groups: normal group (BMI 18.5-23.9 kg/m2), overweight group (BMI >23.9-27.9 kg/m2), and obese group (BMI >27.9 kg/m2). An analysis of the correlation between BMI and IVF was conducted. Results After screening 537 patients were finally included in female BMI group: 433 cases in the normal group, 79 cases in the overweight group and 25 cases in the obese group. 805 patients were eventually included in the male BMI group: 369 cases in the normal group, 299 cases in the overweight group and 137 cases in the obese group. In female BMI group, the age, levels of FSH, E2, LH in female serum, BMI, duration of Gn, the concentration, vitality of male sperm and normal morphology sperm rate were compared among each group, and there was no statistically difference (P > 0.05). The dose of Gn in overweight group and obese group was higher than that in the normal weight group, and the difference was statistically significant (P < 0.05). In male BMI group, the age, basic levels of FSH, E2 and LH in female serum, BMI, dose and duration of Gn, the concentration, vitality of male sperm and normal morphology sperm rate were compared among each group, and there was no statistically difference (P > 0.05). The fertility rate, implantation rate and pregnancy rate of the male obesity group were significantly lower than those of the other two groups, while the abortion rate was significantly higher than that of the normal group, with statistically significant difference (P < 0.05). Conclusion The correlation between increased male BMI and poor IVF outcome might be due to the sperm DNA damage or poor sperm-oocyte interactions, suggesting that couples involved in IVF therapy, especially men, need to maintain an appropriate body weight to reduce poor IVF outcomes risk.

Key words： Infertility Overweight Obesity IVF outcome

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	WANG Jiaxiong SHEN Liyan WANG Wei LI Hong

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WANG Jiaxiong SHEN Liyan WANG Wei LI Hong. Impact of couples′ body mass index on the in vitro fertilization outcomes[J]. 中国医药导报, 2018, 15(20): 67-70.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I20/67

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