高同型半胱氨酸血症的临床研究进展

Abstract
Figure/Table
References (27)
Related Citation (15)

Download: PDF (508 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract The metabolic balance of homocysteine (Hcy) is affected by folic acid and B vitamins. The main reason for the increase of homocysteine is folate deficiency, deficiency of B vitamins and gene mutation of metabolic enzyme. Hyperhomocysteinemia (HHcy) can lead to a variety of diseases such as cardiovascular and cerebrovascular diseases, nervous system diseases, diabetes, adverse pregnancy outcomes, chronic renal diseases, osteoporosis and other diseases. The positive reduction of Hcy levels can benefit the risk of related diseases. The rational supplement of folic acid and B vitamins is an effective measure to control Hcy level and prevent and treat related diseases. This article reviews the clinical research progress of HHcy in order to provide useful reference for the prevention and treatment of related diseases.

Key words： Homocysteine Hyperhomocysteinemia H-hypertension Stroke Folic acid B vitamins

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Guoling ZHANG Lin LIU Guiping▲

Cite this article:

ZHANG Guoling ZHANG Lin LIU Guiping▲. Clinical research progress of hyperhomocysteinemia[J]. 中国医药导报, 2018, 15(20): 29-32.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I20/29

[1] Yang B，Fan S，Zhi X，et al. Prevalence of hyperhomocysteinemia in China：a systematic review and meta-analysis [J]. Nutrients，2014，7（1）：74-90.
[2] Zhou BS，Bu GY，Li M，et al. Tagging SNPs in the MTHFR gene and risk of ischemic stroke in a Chinese population [J]. Int J Mol Sci，2014，15（5）：8931-8940.
[3] Xiao Y，Su X，Huang W，et al. Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism [J]. Int J Biochem Cell Biol，2015，67（10）：158-166.
[4] Bird JK，Ronnenberg AG，Choi SW，et al. Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations [J]. J Nutr，2015，145（1）：79-86.
[5] Shenoy V，Mehendale V，Prabhu K，et al. Correlation of se-rumhomocysteine levels with the severity of coronary artery disease [J]. Indian J Clin Biochem，2014，29（3）：339-344.
[6] Ganguly P，Alam SF. Role of homocysteine in the development of cardiovascular disease [J]. Nutr J，2015，14（1）：6-10.
[7] Osunkalu V，Onajole A，Odeyemi K，et al. Homocysteine and folate levels as indicators of cerebrovascular accident [J]. J Blood Med，2013，33（1）：131-134.
[8] Lei C，Wu B，Liu M，et al. Risk factors and clinical outcomes associated with intracranial and extracranial atherosclerotic stenosis acute ischemic stroke [J]. J Stroke Cerebrovasc Dis，2014，23（5）：1112-1117.
[9] Han L，Wu Q，Wang C，et al. Homocysteine，ischemic stroke，and coronary heart disease in hypertensive patients：a population-based，prospective cohort study [J]. Stroke，2015， 46（7）：1777-1786.
[10] Zhong C，Lv L，Liu C，et al. High homocysteine and blood pressure related to poor outcome of acute ischemia stroke in Chinese population [J]. PLoS One，2014，9（9）：e107 498.
[11] Panel C，Bickel RB，Schnabel E，et al. Homocysteine concentration in coronary artery disease： Influence of three common single nucleotide polymorphisms [J]. Nutr Metab Cardiovasc Dis，2017，27（2）：168-175.
[12] 赵智敏.同型半胱氨酸与心血管疾病的关系研究[J].中国医药指南，2013，11（5）：86-87.
[13] 中华医学会心血管病学分会高血压学组，中华医学会心血管病学分会精准心血管病学学组.H型高血压：同型半胱氨酸水平升高与高血压发生及控制的研究进展[J].中国医学前沿杂志：电子版，2017，9（2）：42-46.
[14] 李建平，卢新政，霍勇，等.H型高血压诊断与治疗专家共识2016[J].中华高血压杂志，2016，24（2）：123-127.
[15] Huang T，Ren JJ，Huang J，et al. Association of homocyteine with type 2 diabets：a meta-analysis implementing Mendelian randomization approach [J]. BMC Genomics，2013，14（1）：867-873.
[16] Petras MI，Tatarkova Z，Kovalska M，et al. Hyperhomocysteinemia as a risk factor for the neuronal system disorders [J]. J Physiol Pharmacol，2014，65（1）：15-23.
[17] Jiang B，Chen Y，Yao G，et al. Effects of differences in serum total homocysteine，folate，and vitamin B12 on cognitive impairment in stroke patients [J]. BMC Neurol，2014， 14（1）：1-5.
[18] Long Y，Nie J. Homocysteine in renal injury [J]. Kidney Dis，2016，2（2）：80-87.
[19] 吴红彦，张光，马小静，等.初诊糖尿病患者高同型半胱氨酸血症与慢性肾脏病相关性研究[J].国际泌尿系统杂志，2017，37（2）：241-245.
[20] 周登诗，黄芳，范大志，等.同型半胱氨酸、叶酸和维生素B12水平与不良妊娠结局的相关性分析[J].中国计划生育学杂志，2017，25（9）：624-626.
[21] 李蓉蓉，沈芸.高同型半胱氨酸血症与骨质疏松的相关性[J].中国老年保健医学，2017，15（2）：73-76.
[22] 李俊，李彬，齐娟，等.联用叶酸、维生素B6和维生素B12降低同型半胱氨酸水平影响心血管疾病风险的荟萃分析[J].中华心血管病杂志，2015，43（6）：554-561.
[23] Ji Y，Tan S，Xu Y，et al. Vitamin B supplementation，homocysteine levels，and the risk of cerebrovascular disease： a meta-analysis [J]. Neurology，2013，81（15）：1298-1307.
[24] Huo Y，Li JP，Qin XH，et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China：The CSPPT randomized clinical trial[J].JAMA，2015，313（13）：1325-1335.
[25] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.中国缺血性脑卒中和短暂性脑缺血发作二级预防指南2014[J].中华神经科杂志，2015，48（4）：258-273.
[26] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组.2015中国脑血管病一级预防指南[J].中华神经科杂志，2015，48（8）：629-643.
[27] Meschia JF，Bushnell C，Boden-Albala B，et al. Guidelines for the primary prevention of stroke：a statement for healthcare professionals from the American Heart Association/American Stroke Association [J]. Stroke，2014，45（12）：3754-3803.