反复上呼吸道感染患儿血清25-羟维生素D3、IL-10和IL-17水平及临床意义

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Abstract Objective To investigate the levels and clinical significances of serum 25-hydroxyvitamin D3 [25(OH)D3], interleukin-10 (IL-10) and interleukin-17 (IL-17) in children with recurrent upper respiratory infection (rURTIs). Methods A total of 60 children with rURTIs in Beijing Luhe Hospital, Capital Medical University from August 2016 to August 2017 were selected as the infection group, 60 healthy children during the same period were selected as control group. Enzyme-linked immunosorbent assay was used to detect levels of serum 25(OH)D3, IL-10 and IL-17. The expression levels of serum 25(OH)D3, IL-10 and IL-17 in two groups were compared. The relationships among three indices and the clinical significances with rURTIs were observed. Results The levels of serum 25(OH)D3 and IL-10 in rURTIs in infected group were significantly lower than those in control group, while the level of IL-17 was significantly higher than that in the control group, the differences were all statistically significant (P < 0.01); the levels of serum 25(OH)D3 and IL-10 of rURTIs in infected children of 0-2 years old were significantly lower than those of ＞2-6 years old ones, the level of IL-17 was significantly higher than that of ＞2-6 years old ones, and the differences were all statistically significant (P < 0.01). Pearson correlation analysis showed that the serum 25(OH)D3 was positively correlated with IL-10 in children with rURTIs (r = 0.647, P = 0.000), and had significant negative correlation between serum 25(OH)D3 and IL-17 in children with rURTIs (r = -0.774, P = 0.000), and had significant negative correlation between serum IL-10 and IL-17 in children with rURTIs (r = -0.467, P = 0.000). Multivariate analysis of COX showed that age, BMI, 25(OH)D3, IL-10 and IL-17 were independent influnce factors to rURTIs (P < 0.05). Conclusion The levels of serum 25(OH)D3 and IL-10 decrease, while the level of IL-17 increase significantly in children with rURTIs. 25(OH)D3 deficiency may be an important reason for the down-regulation of serum IL-10 and the up-regulation of IL-17 in children with rURTIs.

Key words： Repeated upper respiratory tract infection 25-hydroxyvitamin D3 Interleukin-10 Interleukin-17 Clinical significance

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	LIU Wei

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LIU Wei. Levels and clinical significances of serum 25-hydroxyvitamin D3, IL-10 and IL-17 in children with recurrent upper respiratory infection[J]. 中国医药导报, 2018, 15(18): 80-83.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I18/80

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