欧龙马滴剂用于小儿鼻-鼻窦炎的近远期疗效及安全性观察

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Abstract Objective To explore the long-term efficacy of Oulongma Drops in children with nasal sinusitis and to analyze the safety of treatment. Methods A total of 300 cases of nasal-sinusitis were enrolled in Zhuozhou City Hospital from January 2016 to January 2017. They were divided into 100 cases of group A, B and C according to the random number table, patients of the group A and group B were treated with Oulongma Drops, 1-6-year-old children of group A with starting dose of 4 mL/time, after 5 d adjusted to 2 mL/time, >6-12 years old children 6 mL/time, after 5 d to 3 mL/time, 1-6 years old children of group B were given the dose of 2 mL/time, >6-12 years old mL/time, group C was given Mu Shu Tan syrup treatment, 1-6 children 2.5 mL/time, >6-12 years old 5 mL/time. The clinical efficacy of the two groups in 1 and 3 months after treatment were observed, and the recurrence rate was analyzed after 8 months follow-up. The nasal, mucosal hyperemia, sleep disorders, runny nose scores were assessed by the nasal sinus outcome test-20 (SNOT-20) scale and the adverse events were recorded. Results The total effective rates of group A and group B were 90.0% and 89.0% respectively, which were higher than that of group C (72.0%), the difference was statistically significant (P < 0.05). The total effective rate of group A, B and C after 3 months was 88.0%, 86.0%, 61.0%, and the recurrence rate was 2.0%, 3.0% and 11.0% respectively， the total effective rate of group C was lower than that of A and B group, the recurrence rate was higher than that of group A and B, the differences were statistically significant (P < 0.05). The scores of nasal congestion and mucosal congestion were lower in group A and group B than those in group C (P < 0.05). The incidence of adverse reactions in group B was 2.0%, which was lower than that in group A and group C (9.0%, 9.0%), the difference was statistically significant (P < 0.05). Conclusion Compared with the Mu Shu Tan syrup, the Oulongma Drops can further improve the nasal sinusitis in children with symptoms, curative effect is distinct, the small dosage of medicine not only can obtain ideal therapeutic effect, but also with low incidence of adverse reactions, worthy of clinical promotion.

Key words： Rhinosinusitis Olongma Drops Therapeutic effect Security

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	MENG Xiangtao1 YANG Xiao2

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MENG Xiangtao1 YANG Xiao2. Long-term efficacy and safety of Oulongma Drops in children with nasal-sinusitis[J]. 中国医药导报, 2018, 15(18): 76-79.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I18/76

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