血清、滑液中肿瘤坏死因子-α在痛风性关节炎中的表达及临床意义

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (472 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To study the expression and clinical significance of tumor necrosis factor-α (TNF) in serum and synovial fluid in patients with gouty arthritis (GA). Methods Eighty GA patients in First Affiliated Hospital of Kunming Medical University from December 2016 to November 2017 were selected as the observation group and then divided into two subgroups according to the severity of the disease: observation group 1 (36 cases, severe) and observation group 2 (44 cases, mild). Both were treated with colchicine and etoricoxib. Sixty healthy people were selected as the control group at the same time. The treatment outcome were record and the levels of TNF-α in serum and synovial fluid were detected in the three groups. The expression of TNF-α in serum and synovial fluid of patients with different therapeutic effects and during treatment were compared. Results Thirty-one cases were cured, 24 cases were markedly effective, 21 cases were effective, 4 cases were ineffective, the markedly effective rate was 68.75%. The TNF-α levels of serum and synovial fluid in the observation group 1 and group 2 at admission were significantly higher than those of the control group, with statistically significant differences (P ＜ 0.05). The level of TNF-α in synovial was significantly higher than that of serum in the observation group (P ＜ 0.05). At the treatment of 10 d and 2 weeks, the TNF-α level in serum and synovial fluid in the observation group 1 and group 2 were significantly lower than those of admission (P ＜ 0.05). The TNF-α level in synovial fluid in the effective group were significantly lower than that of ineffective group at admission and 2 weeks after treatment; 2 weeks after treatment, the TNF-α level in serum and synovial fluid were all higher than those of admission, with statistically significant differences (P ＜ 0.05). Conclusion The level of TNF-α in serum and synovial from GA patients are significantly higher than healthy people. To monitor the level of TNF-α in the synovial fluid of the affected limb is helpful to evaluate the therapeutic effect and guide clinical intervention.

Key words： Gouty arthritis Tumor necrosis factor-α Serum Synovial fluid

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LAI Aiyun XU Jian TAO Li

Cite this article:

LAI Aiyun XU Jian TAO Li. The expression and clinical significance of TNF-α in serum and synovial fluid in patients with gouty arthritis[J]. 中国医药导报, 2018, 15(18): 60-63.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I18/60

[1] 于泓，袁良东，钟正霞，等.抗痛风胶囊治疗大鼠急性痛风性关节炎及下调TNF-α水平[J].重庆医学，2012，41（22）：2273-2275.
[2] 梁翼，李敏，吴晓惠，等.IL-1β、IL-6、TNF-α与急性痛风性关节炎的相关性研究[J].中国中医骨伤科杂志，2014， 22（9）：14-16.
[3] Ghosh P，Cho M，Rawat G，et al. Treatment of Acute Gouty Arthritis in Complex Hospitalized Patients With Anakinra [J]. Arthrit Care Res，2013，65（8）：1381-1382.
[4] 邹和建，姜林娣.2012年美国风湿病学会痛风治疗指南评析[J].内科理论与实践，2012，7（6）：458-460.
[5] 周蜜，王一飞，周茹，等.系列痛风颗粒联合金黄膏分期治疗痛风性关节炎疗效观察[J].中国中西医结合杂志，2013，33（12）：1603-1607.
[6] 王瑜，何曼，赵景新，等.关节镜下清理术治疗膝关节痛风性关节炎[J].中国临床研究，2015，28（8）：1000-1002.
[7] 李利生，史源泉，龚其海.淫羊藿苷抗尿酸钠诱导的大鼠急性痛风性关节炎作用[J].中国实验方剂学杂志，2017， 23（11）：134-138.
[8] 尹如兰，符婷，李立人，等.痛风患者降尿酸药物服用依从性影响因素的研究进展[J].风湿病与关节炎，2017，6（4）：75-80.
[9] 李迎春，徐建华.急性痛风性关节炎的发病机制及研究进展[J].安徽医学，2013，34（1）：96-98.
[10] 于泓，袁良东，姚观平，等.抗痛风胶囊对急性痛风性关节炎大鼠的抗炎作用及机制探讨[J].中国实验方剂学杂志，2013，19（6）：283-286.
[11] 朱芳晓，周润华，莫汉有，等.通滞苏润江胶囊治疗急性痛风性关节炎的临床研究及对IL-1β、TNF-α的影响[J].时珍国医国药，2013，24（3）：687-689.
[12] 石慧，王丹彤，乌日嘎，等.TNF-α介导的NF-κB信号通路在类风湿性关节炎血管形成中的作用[J].医学综述，2012，18（15）：2397-2400.
[13] 王晓璐，徐静，李慧，等.五藤痛风饮对大鼠急性痛风性关节炎模型的IL-8、TNF-α的影响[J].中国现代药物应用，2013，7（13）：6-7.
[14] 陈文，王沛明，张祎，等.基于TLR4通路初探黄芩对内毒素血症大鼠肝肺组织中细胞因子IL-1β、IL-6、TNF-a以及氧化应激因子MDA、SOD水平的影响[J].中药药理与临床，2016，32（3）：87-92.
[15] 范治伟，路晓光，康新，等.7.5%高渗盐水对失血性休克患者炎性因子及氧自由基的作用[J].中华卫生应急电子杂志，2015，1（1）：26-30.
[16] 高丽萍，李荣振，颜小荣.烧伤膏对烧伤模型大鼠早期IL-1、TNF-α、氧自由基的干预研究[J].社区医学杂志，2016，14（23）：41-43.
[17] Stam TC，Swaak AT，Kruit WH，et al. Intrapleural administration of tumour necrosis factor-alpha（TNFα）in patients with mesothelioma：cytokine patterns and acute-phase protein response [J]. Eur J Clin Invest，2015，30（4）：336-343.
[18] 阮华玲，赵黎，郭昆全，等.甲状腺功能亢进症患者氧自由基代谢及游离氨基酸变化研究[J].海南医学院学报，2016，22（8）：768-770.
[19] 倪洪岗，杨娟，李莉.自拟痛风消经验汤剂对急性痛风性关节炎患者血清UA、ESR、IL-1β、TNF-α、COX-2水平的影响[J].辽宁中医杂志，2017，44（3）：525-528.
[20] 孙文才，白玉江，李玉成，等.骨关节炎患者血清及关节滑液中细胞因子的表达水平研究[J].中国全科医学，2012， 15（27）：3185-3186.