ATF4基因与肿瘤

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Abstract Activating transcription factor 4 (ATF4) belongs to the ATF/CREB family and plays an important role in stress responses such as hypoxia, amino acid deletion, oxidative stress and endoplasmic reticulum stress. In most tumors, the expression of ATF4 is up-regulated, and it can enhance the hypoxia tolerance of tumors and promote the expression of tumor growth and angiogenic factors, and then participate in the process of regulating the development of tumor. Therefore, ATF4 may be a potential new target in the field of tumor therapy. This paper reviewed the related advances of ATF4 gene in tumor research.

Key words： Tumor Activating transcription factor 4 Endoplasmic reticulum stress

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	WANG Hui1 LIU Qinjiang2

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WANG Hui1 LIU Qinjiang2. ATF4 gene and tumor[J]. 中国医药导报, 2018, 15(18): 36-39.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I18/36

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