儿童肺炎支原体肺炎血清sB7-H3及相关细胞因子的水平变化及临床意义

Abstract
Figure/Table
References (20)
Related Citation (3)

Download: PDF (532 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the relationship between serum sB7-H3 and related cytokines, and to evaluate its process in the development of Mycoplasma Pneumoniae pneumonia (MPP) through the analysis of the expression of serum soluble B7-H3 (sB7-H3) and related cytokines in MPP. Methods 110 cases children with MPP in the Fourth Hospital of Hebei Medical University from January 2016 to January 2017 were selected as the MPP group and divided into severe MPP group (54 cases), mild MPP group (56 cases) according to the condition of children. In addition, healthy children were selected as the normal control group (38 cases). The levels of sB7-H3, IFN-γ, GM-CSF, IL-4 and IL-17 in serum of MPP were detected by automatic microplate reader. Results The levels of sB7-H3, IFN-γ, GM-CSF and IL-17 in the serum of MPP children was significantly higher than those in the recovery phase and the control group (P < 0.05). The expression level of IL-4 in acute phase was lower than that in recovery phase and control group (P < 0.05). The levels of serum in the recovery phase of the MMP group was significantly higher than those in the control group (P < 0.05). IL-4 levels was lower than those in the control group. The levels of sB7-H3, IFN-γ, GM-CSF and IL-17 in the serum of MPP group were significantly higher than those of mild MPP (P < 0.05). There was no statistical difference in IL-4 levels between the two groups (P > 0.05). Serum level of sB7-H3 was positively correlated with IFN- and GM-CSF in acute phase of MPP (r = 0.573, 0.682, all P < 0.01), but not significantly related to the levels of IL-4 and IL-17 (P > 0.05). Conclusion sB7-H3 and cytokines IFN-γ, GM-CSF, IL-4 and IL-17 play an important role in the infection of children with MPP and participate in the pathogenesis of MPP.The levels of them is related to the severity of the disease.

Key words： Mycoplasma Pneumoniae Pneumonia Soluble B7-H3 Cytokines

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XIN Sufang1 LI Limin1 BIAN Li2

Cite this article:

XIN Sufang1 LI Limin1 BIAN Li2. The clinical significance and changes of serum sB7-H3 and related cytokines in children with Mycoplasma Pneumoniae pneumonia[J]. 中国医药导报, 2017, 14(30): 108-111.

URL:

http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I30/108

[1] Li W，Fang YH，Shen HQ，et al. Evaluation of a real-time method of simultaneous amplification and testing in diagnosis of Mycoplasma pneumoniae infection in children with pneumonia [J]. PLoS One，2017，12（5）：e0177842.
[2] Zhao JL，Wang X，Wang YS. Relationships between Th1/Th2 cytokine profiles and chest radiographic manifestations in childhood Mycoplasma Pneumoniae pneumonia [J]. Ther Clin Risk Manag，2016，12：1683-1692.
[3] Yang HJ，Song DJ，Shim JY，et al. Mechanism of resistance acquisition and treatment of macrolide-resistant Myco?鄄plasma pneumoniae pneumonia in children [J]. Korean J Pediatr，2017，60（6）：167-174.
[4] 贾云霞.儿童重症支原体肺炎60例诊治分析[J].山西医药杂志，2015（8）：939-941.
[5] 仝玲.小儿肺炎支原体肺炎合并全身炎症反应综合征时炎性相关因素的变化及临床意义[J].临床心身疾病杂志，2015，21（s1）：347-350.
[6] 吴小磊，张慧玉，田玲，等.儿童肺炎支原体肺炎血清和肺泡灌洗液中T细胞亚群及细胞因子检测的意义[J].儿科药学杂志，2015，21（4）：6-9.
[7] Chen ZR，Zhang GB，Wang YQ，et al. Soluble B7-H3 elevations in hospitalized children with Mycoplasma pneumoniae pneumonia [J]. Diagn Microbiol Infect Dis，2013， 77（4）：362-366.
[8] 朱春梅，曹玲.小儿肺炎支原体肺炎诊治——重症支原体肺炎并发症的诊治[J].中国实用儿科杂志，2015，30（3）：161-165.
[9] Hanzawa F，Fuchigami T，Ishii W，et al. A 3-year-old boy with Guillain-Barre syndrome and encephalitis associated with Mycoplasma pneumoniae infection [J]. J Infect Chemo?鄄ther，2014，20（2）：134-138.
[10] Chen Z，Zhao X，Zhang X，et al. Increased concentrations of soluble B7-H3 and interleukin 36 in bronchoalveolar lavage fluid of Children with Mycoplasma pneumoniae pneumonia [J]. BMC Infect Dis，2016，16：212.
[11] Chen ZR，Zhang GB，Wang YQ，et al. Soluble B7-H3 elevations in hospitalized children with Mycoplasma pneumoniae pneumonia [J]. Diagn Microbiol Infect Dis，2013， 77（4）：362-366.
[12] Shao L，Cong Z，Li X，et al. Changes in levels of IL-9，IL-17，IFN-γ，dendritic cell numbers and TLR expression in peripheral blood in asthmatic children with Mycoplasma pneumoniae infection [J]. Int J Clin Exp Pathol，2015，8（5）：5263-5272.
[13] 孟战备.难治性肺炎患儿细胞因子水平变化及意义[J].中外医疗，2015，34（18）：25-26.
[14] R?sler B，Herold S. Lung epithelial GM-CSF improves host defense function and epithelial repair in influenza virus pneumonia-a new therapeutic strategy? [J]. Mol Cell Pediatr，2016，3（1）：29.
[15] Medjo B，Atanaskovic-Markovic M，Nikolic D，et al. Increased serum Interleukin-10 but not Interleukin-4 level in children with Mycoplasma Pneumoniae pneumonia [J]. J Trop Pediatr，2017，63（4）：294-300.
[16] 孙立峰，鞠云飞，陈星，等.肺炎支原体肺炎急性期患儿血清Th1/Th2类细胞因子水平变化及临床意义[J].山东医药，2010，50（49）：49-52.
[17] 梁粤.肺炎支原体肺炎患儿外周血IL-10/IL-17表达与肺功能变化的相关性研究[J].临床儿科杂志，2015，33（8）：686-689.
[18] 赵桐，杨安钢，温伟红.Th17细胞分化及其参与肿瘤免疫的研究进展[J].中国免疫学杂志，2016，32（1）：111-115.
[19] 张微，杨萍萍，迟立君.辅助性T细胞17在神经系统变性疾病中的研究进展[J].医学综述，2017，23（12）：2318-2322.
[20] 陆敏，付汉东，张爱华，等.肺炎支原体感染患儿血清IL-17、IL-23表达及临床意义[J].中华全科医学，2012， 10（3）：374-376.