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| Preventive effect of Yiqi Huoxue Tongluo Decoction on lower extremity deep venous thrombosis in patients underwent total hip replacement |
| BAI Minghua1 CHENG Lei2 ZHANG Ziqiang1 |
1.The First Department of Bone Traumatology, Baoji Hospital of Traditional Chinese Medicine, Shaanxi Province, Baoji 721000, China;
2.the Second Department of Spinal Bone Traumatology, Baoji Hospital of Traditional Chinese Medicine, Shaanxi Province, Baoji 721000, China |
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Abstract Objective To observe the preventive effect of Yiqi Huoxue Tongluo Decoction in lower extremity deep venous thrombosis after total hip replacement. Methods One hundred and seventy-four patients underwent total hip replacement in Baoji Hospital of Traditional Chinese Medicine from January 2015 to April 2017 were selected as research objects, and they were randomly assigned into control group and observation group by random number table, with 87 cases in each group. The control group was given low molecular weight heparin calium by subcutaneous injection, on basis of which, the observation group was added with Yiqi Huoxue Tongluo Decoction. The parameters of coagulation function [prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-Dimer (D-D)] and blood platelet count (PLT) were detected before operation and after operation for 1, 7, 14 days. The intraoperative blood loss, postoperative volume of drainage and total blood transfusion volume of the two groups were collected. Follow-up for 3 months after operation, the incidence of lower extremity deep venous thrombosis of the two groups was recorded. Results Through analysis of variance, the differences of PT, TT, APTT, FIB, D-D and PLT at different time points were statistically significant (P ＜ 0.05), the treatment factors and timing showed no reciprocal action (P ＞ 0.05), the PT, TT, APTT, FIB, D-D and PLT among different treatment factors had no statistically significant differences (P ＞ 0.05). The intraoperative blood loss and total blood transfusion volume between the two groups had no statistically significant differences (P ＞ 0.05). The postoperative volume of drainage in the observation group was less than that of control group, the difference was statistically significant (P ＜ 0.05). During follow-up, 7 cases in observation group and 5 cases in control group failed to finish the study. The incidence of lower extremity deep venous thrombosis in the observation group was 21.25% (17/80), which was lower than that of control group [35.37% (29/82)], the difference was statistically significant (P ＜ 0.05). Conclusion Yiqi Huoxue Tongluo Decoction has significant anticoagulation, thrombolysis effects, which can significantly improve clinical symptoms, reduce postoperative volume of drainage, decrease the incidence of lower extremity deep venous thrombosis after total hip replacement, it is worthy of clinical promotion and application.
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