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| Effect of synchronized intermittent mandatory ventilation on blood gas indexes in neonates with respiratory failure |
| YAO Heping XU Peilin Wang Yingying |
| Department of Neonatology, Shaoxing Central Hospital, Zhejiang Province, Shaoxing 312000, China |
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Abstract Objective To investigate the effect of synchronized intermittent mandatory ventilation (SIMV) on blood gas indexes in neonates with respiratory failure. Methods From June 2015 to June 2017, in NICU of Shaoxing Central Hospital, 116 neonates with respiratory failure were selected, according to the choice of ventilation mode, they were divided into SIMV group (60 cases, given SIMV ventilation) and continuous positive airway pressure (CPAP) group (56 cases, given CPAP). The clinical curative effect, blood gas indexes (PaCO2, PaO2, SpO2, OI) 3 d after treatment, the proportion of intubation and ventilator setting, duration of ventilation, hospital stay and incidence of complications in the two groups were compared. Results The effective rate in SIMV group was 93.33%, that in CPAP group was 80.36%, the difference was not statistically significant (P > 0.05). 3 d after treatment, the PaCO2 in SIMV group [(36.21±4.38) mmHg] was significantly lower than that in CPAP group [(42.54±5.19) mmHg], the difference was statistically significant (P < 0.05), while the PaO2, SpO2 and OI [(63.29±5.19) mmHg, (0.95±0.08), (239.54±36.41)] were significantly higher than those in CPAP group [(57.19±5.09) mmHg, (0.91±0.09), (222.96 ±32.48)], the differences were statistically significant (P < 0.05). The duration of ventilation, hospital stay, the proportion of intubation and ventilator setting, the total incidence of complications in SIMV group [(34.12±10.78) h, (15.13±4.29), 8.33%, 20.00%] were compared with CPAP group [(48.75±12.49) h, (18.64±5.31) d, 25.00%, 44.64%], the differences were statistically significant (P < 0.05). Conclusion The curative effect of SIMV is obvious in neonates with respiratory failure. It can improve blood gas indexes, shorten the duration of ventilation and reduce intubation and complications.
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