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| Study on the effects of Somatostatin, Pituitrin and Omeprazole triple therapy in the treatment of cirrhosis with hemorrhage of gastroesophageal varices in serum GAS, GLC and hemodynamics |
| LI Chao |
| Department of Emergency Center, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110034, China |
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Abstract Objective To investigate the effects of Somatostatin, Pituitrin and Omeprazole triple therapy in the treatment of cirrhosis with hemorrhage of gastroesophageal varices in serum GAS, GLC and hemodynamics. Methods From December 1, 2012 to June 5, 2016, 117 cases of cirrhosis with hemorrhage of gastroesophageal varices were collected in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, according to the type of treatment, were randomly divided into Somatostatin group, Pituitrin group and combined group, with 39 cases in each group, Somatostatin group was treated with Somatostatin+Omeprazole, Pituitrin group were treated with Pituitrin+Omeprazole and the combined group were treated with Somatostatin+Pituitrin+Omeprazole, and three groups were treated for 24 to 48 h. The pressure, portal venous pressure, portal vein diameter, portal vein blood flow velocity of central vein were measured, the determination of GAS and GLC in blood samples were collected and clinical effect, dynamic changes, adverse events were compared after treatment. Results Compared with that before treatment, PVP, DPV value, GAS, and GLC of the three groups after treatment decreased, the differences were statistically significant （P < 0.05). Compared with Pituitrin group and Somatostatin group, levels of PVP and DPV were lower, GAS and GLC were lower, the differences were statistically significant （P < 0.05). The improved rate of the Pituitrin group （74.36%) and Somatostatin group （71.79%) were lower than the combined group （92.31%), the difference was statistically significant （P < 0.05). The hemostatic time, average blood transfusion and hospitalization time of the Pituitrin group and the Somatostatin group were higher than the combined group （P < 0.05). Conclusion Somatostatin, Pituitrin and Omeprazole triple therapy can improve the liver cirrhosis with esophageal and gastric variceal bleeding bleeding, reduce portal vein pressure, gastrointestinal hormone, is a kind of effective treatment.
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