AIRE因子在重症肌无力患者外周血中的表达及其影响

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Abstract Objective To study the expression and influencing factors of AIRE in peripheral blood of MG. Methods Clinical data and peripheral blood samples of MG patients were collected at Tangdu Hospital of air force Military Medical University from January 2016 to January 2017. All data were divided into general type MG (GMG) group (16 cases), ocular MG (OMG) group (14 cases) and control group (10 cases). Flow cytometry was used to analyze the ratio of AIRE positive cells, Tfr cells and Tfh cells. Results The express of AIRE in GMG group was significantly lower than that in OMG group and control group (P=0.003), but there was no significant difference between OMG group and control group (P=0.152). The express of AIRE was positively correlated with the ratio of Tfr/Tfh (r=0.605, P ＜ 0.001), but negatively correlated with the QMG score and clinical absolute score (r=-0.622, P ＜ 0.001; r=-0.513, P=0.004). Conclusion AIRE may be involved in the pathogenesis of MG, and low level of AIRE may play a key role in the pathogenesis of MG.

Key words： Autoimmune regulator Myasthenia gravis Quantitative MG score Clinical absolute score

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	WANG Shengyuan1* XIAO Fenglin2* LI Hang1 ZHANG Yu1

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WANG Shengyuan1* XIAO Fenglin2* LI Hang1 ZHANG Yu1. The expression and influencing factors of AIRE in peripheral blood of myasthenia gravis[J]. 中国医药导报, 2018, 15(13): 47-50.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I13/47

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