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| Study of cognitive function in ultra-high-risk psychosis population and first episode schizophrenia |
| ZHANG Rongrong YAN Wei LV Lanlan XIE Shiping▲ |
| The Second Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Jiangsu Province, Nanjing 210029,China |
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Abstract Objective To evaluate the cognitive function of patients with the first episode schizophrenia and Ultra-high-risk for psychosis and figure out the cognitive function of schizophrenia in different periods and related factors. Methods Twenty-eight patients with first episode schizophrenia (first episode group) and 24 patients with ultra-high-risk for psychosis (UHR group) were treated in Affiliated Nanjing Brain Hospital of Nanjing Medical University from May 2017 to February 2018 were selected, and 38 well-matched healthy controls (control group) were assessed with the Wechsler Adult Intelligence Scale for intelligence and MATRICS Consensus Cognitive Battery (MCCB) for cognitive function, the differences of cognitive function among the three groups were compared, while the correlation analysis was carried out. Results The difference of the scores of IQ, speed of processing, verbal learning, working memory, reasoning, visual learning, social cognition and attention/vigilance in three groups was significant (P < 0.05). Compared with the control group, both the first episode group and UHR group showed worse performance in IQ, speed of processing, verbal learning, working memory, reasoning, visual learning, social cognition and attention/vigilance (P < 0.05), compared with the UHR group, first episode group showed worse performance in speed of processing, verbal learning, working memory, visual learning, social cognition (P < 0.05). The positive symptoms of UHR group were negatively correlated with the scores of TMT and NAB, the negative symptoms were negatively correlated with the scores of TMT, BACS, Fluency, WMS, NAB, BVMT-R, CPT-IP, (P < 0.05) IQ were positively correlated with the scores of TMT, BACS, Fluency, HVLT-R, NAB, CPT-IP (P < 0.05). Conclusion Widespread cognitive impairments exist in ultrahigh-risk psychosis and the impairments may start before the onset of the disease, and cognitive function will aggravate with the progression of the disease.
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[1] Shmukler AB，Gurovich IY，Agius M，et al. Long-term trajectories of cognitive deficits in schizophrenia：A critical overview [J]. European Psychiatry，2015，30（8）：1002-1010.
[2] Hedman AM，van Haren NE，van Baal CG，et al. IQ change over time in schizophrenia and healthy individuals：a meta-analysis [J]. Schizophr Res，2013，146（1-3）：201-208.
[3] Bora E，Murray RM. Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis：do the cognitive deficits progress over，or after，the onset of psychosis? [J]. Schizophr Bull，2014，40（4）：744-755.
[4] Schvarcz A，Bearden CE. Early Detection of Psychosis：Recent Updates from Clinical High-Risk Research [J]. Curr Behav Neurosci Rep，2015，2（2）：90-101.
[5] Tandy M，Thomas M，Lifshey RJ，et al. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes：preliminary evidence of interrater reliability and predictive validity [J]. Am J Psychiatry，2002，159（5）：863-865.
[6] 张明园.精神科评定量表手册[M].长沙：湖南科学技术出版社，2003：66-67.
[7] Kay S，Opler L，Lindenmayer J. The Positive and Negative Syndrome Scale （PANSS）：Rationale and Standardisation [J]. Br J Psychiatry Suppl，1989，（7）：59-67.
[8] Kern S，Keith H，Michael F. The MATRICS Consensus Cognitive Battery，Part 2Co-Norming and Standardization [J]. Am J Psychiatry，2008，165（2）：214-220.
[9] Alice M，Rosa L. Treatment of cognitive dysfunction in psychiatric disorders [J]. J Psychiatr Pract，2004，10（1）：17-25.
[10] Liu CC，Hua MS，Hwang TJ，et al. Neurocognitive functioning of subjects with putative pre-psychotic states and early psychosis [J]. Schizophr Res，2015，164（1-3）：40-46.
[11] Hou CL，Xiang YT，Wang ZL，et al. Cognitive functioning in individuals at ultra-high risk for psychosis，first-degree relatives of patients with psychosis and patients with first-episode schizophrenia [J]. Schizophr Res，2016，174（1-3）：71-76.
[12] Frommann I，Pukrop R，Brinkmeyer J，et al. Neuropsychological profiles in different at-risk states of psychosis：executive control impairment in the early--and additional memory dysfunction in the late-prodromal state [J]. Schizophr Bull，2011，37（4）：861-873.
[13] 范敏珍，吴逢春，郑洪波.精神分裂症超高危人群及首次发病患者的认知功能研究[J].临床精神医学杂志，2014（1）：11-3.
[14] Freedman D，Brown AS. The developmental course of executive functioning in schizophrenia [J]. Int J Dev Neurosci，2011，29（3）：237-243.
[15] Bliksted V，Fagerlund B，Weed E，et al. Social cognition and neurocognitive deficits in first-episode schizophrenia [J]. Schizophr Res，2014，153（1-3）：9-17.
[16] McCleery A，Ventura J，Kern RS，et al. Cognitive functioning in first-episode schizophrenia：MATRICS Consensus Cognitive Battery （MCCB） Profile of Impairment [J]. Schizophr Res，2014，157（1-3）：33-39.
[17] Barbara R，Beata H. Executive functioning improves after remission of psychosis and may not deteriorate at short follow-up in early-onset schizophrenia [J]. Neuro Endocrinol Lett，2015，36（2）：153-160.
[18] 何宗岭，黄吉林，李涛，等.首发精神分裂症患者治疗前后认知功能损害的比较[J].中国神经精神疾病杂志，2013（7）：411-415.
[19] 胡春水，李君，田源，等.长期住院对慢性精神分裂症患者认知功能的影响[J].中国医药导报，2017，14（8）：60-3.
[20] 张治坤，孙华，张荣，等.精神分裂症患者及其一级亲属认知功能和阴性症状相关性研究[J].临床精神医学杂志，2017（2）：123-125.
[21] Bergh S，Hjorthoj C，Sorensen HJ，et al. Predictors and longitudinal course of cognitive functioning in schizophrenia spectrum disorders，10years after baseline：The OPUS study [J]. Schizophr Res，2016，175（1-3）：57-63.
[22] Akiyama K，Saito S，Saito A，et al. Predictive value of premorbid IQ，negative symptoms，and age for cognitive and social functions in Japanese patients with schizophrenia：A study using the Japanese version of the Brief Assessment of Cognition in Schizophrenia [J]. Psychiatry Res，2016， 246：663-671. |
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