miR-375在肿瘤发生及诊断中的研究进展

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Abstract MicroRNAs (miRNAs) are conserved small non-coding RNAs that play important roles in various biological processes via controlling gene expression. Among them, miR-375 is firstly identified in pancreatic β-cells and proved to regulate insulin secretion and islet formation. Furthermore, it turns that miR-375 is involved in cancer development and progression by targeting several important oncogenes including AEG-1, YAP1, IGF1R and PDK1. Unlike some other cancers, the levels of miR-375 in prostate and breast cancer specifically increase, indicating its action in tumor development. Therefore, miR-375 may be a potential target for suppressing tumor growth, and has the clinical value as a biomarker for early diagnosis and prognosis prediction.

Key words： miR-375 Pancreatic β-cells Tumor Diagnosis

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	SUI Chengliang1 HUANG Zhaoquan2

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SUI Chengliang1 HUANG Zhaoquan2. Advanced in the research of miR-375 on tumor development and diagnosis[J]. 中国医药导报, 2018, 15(13): 35-37,46.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I13/35

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